ArticleProceedings of the National Academy of Sciences of the United States of America2013
Differential effects of global versus local testosterone on singing behavior and its underlying neural substrate.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
61 citing papers in PubMed, 125 citations in OpenAlex.
- Anesthetic and analgesic management of Svalbard rock ptarmigan (Lagopus muta hyperborea) undergoing experimental stereotaxic neurosurgery.BMC veterinary research · 2025Article
- From silence to song: Testosterone triggers extensive transcriptional changes in the female canary HVC.Journal of neuroendocrinology · 2025Article
- Neurochemical Characterization of Dopaminoceptive Cells in Song Control Nuclei of Canaries and Their Activation During Song Production: A Multiplex Fluorescent In Situ Hybridization Study.The Journal of comparative neurology · 2024Article
- Song system neuroanatomy, and immediate early gene expression in a finch species with extensive male and female song.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2024Article
- Androgen signaling in LMAN regulates song stereotypy in male canaries.Hormones and behavior · 2024Article
- The molecular architecture of a complex social behavior: gregarious song.BMC neuroscience · 2023Article
- Steroid-dependent plasticity in the song control system: Perineuronal nets and HVC neurogenesis.Frontiers in neuroendocrinology · 2023Review
- Contribution of birds to the study of sexual differentiation of brain and behavior.Hormones and behavior · 2023Article
- Breaking Through the Bottleneck: Krogh's Principle in Behavioral Neuroendocrinology and the Potential of Gene Editing.Integrative and comparative biology · 2023Review
- Does the syrinx, a peripheral structure, constrain effects of sex steroids on behavioral sex reversal in adult canaries?Hormones and behavior · 2023Article
- Genetic dissection of steroid-hormone modulated social behavior: Novel paralogous genes are a boon for discovery.Hormones and behavior · 2023Review
- A brain for all seasons: An in vivo MRI perspective on songbirds.Journal of experimental zoology. Part A, Ecological and integrative physiology · 2022Review
- The neural distribution of the avian homologue of oxytocin, mesotocin, in two songbird species, the zebra finch and the canary: A potential role in song perception and production.The Journal of comparative neurology · 2022Article
- Motivational increase of androgens and behavior by infant distress calls in highly responsive common marmoset fathers, Callithrix jacchus.Hormones and behavior · 2022Article
- Using seasonality and birdsong to understand mechanisms underlying context-appropriate shifts in social motivation and reward.Hormones and behavior · 2022Review
- Article
- Unraveling the Role of Thyroid Hormones in Seasonal Neuroplasticity in European Starlings (Frontiers in molecular neuroscience · 2022Article
- Birdsong and the Neural Regulation of Positive Emotion.Frontiers in psychology · 2022Review
- Testosterone amplifies the negative valence of an agonistic gestural display by exploiting receiver perceptual bias.Proceedings. Biological sciences · 2021Article
- Article
1 more citing papers are in PubMed but not listed here.
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
Steroid hormones regulate multiple but distinct aspects of social behaviors. Testosterone (T) has multiple effects on learned courtship song in that it regulates both the motivation to sing in a particular social context as well as the quality of song produced. The neural substrate(s) where T acts to regulate the motivation to sing as opposed to other aspects of song has not been definitively characterized. We show here that T implants in the medial preoptic nucleus (POM) of castrated male canaries (Serinus canaria) increase song rate but do not enhance acoustic features such as song stereotypy compared with birds receiving peripheral T that can act globally throughout the brain. Strikingly, T action in the POM increased song control nuclei volume, consistent with the hypothesis that singing activity induces neuroplasticity in the song control system independent of T acting in these nuclei. When presented with a female canary, POM-T birds copulated at a rate comparable to birds receiving systemic T but produced fewer calls and songs in her presence. Thus, POM is a key site where T acts to activate copulation and increase song rate, an appetitive sexual behavior in songbirds, but T action in other areas of the brain or periphery (e.g., HVC, dopaminergic cell groups, or the syrinx) is required to enhance the quality of song (i.e., stereotypy) as well as regulate context-specific vocalizations. These results have broad implications for research concerning how steroids act at multiple brain loci to regulate distinct sociosexual behaviors and the associated neuroplasticity.
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