ArticleProceedings of the National Academy of Sciences of the United States of America2013
Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
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Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- The molecular genetics of human appendicular skeleton.Molecular genetics and genomics : MGG · 2022Pooled it
- Permissive and instructiveeLife · 2026Article
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- A single-cell and tissue-scale analysis suite resolves Mixl1's role in heart development.iScience · 2025Article
- Thalidomide-induced limb malformations: an update and reevaluation.Archives of toxicology · 2025Review
- Deficiency of UBE3D in mice leads to severe embryonic abnormalities and disrupts the mRNA of Homeobox genes via CPSF3.Cell death discovery · 2025Article
- The 3' region of the ZPA regulatory sequence (ZRS) is required for activity and contains a critical E-box.Frontiers in cell and developmental biology · 2025Article
- Multimodal spatiotemporal transcriptomic resolution of embryonic palate osteogenesis.Nature communications · 2023Article
- Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma.Biomedicines · 2023Article
- Characterization of a novel Hoxa5eGFP mouse line.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- A single-cell transcriptome atlas profiles early organogenesis in human embryos.Nature cell biology · 2023Article
- How might we build limbsFrontiers in cell and developmental biology · 2023Review
- The Cdx transcription factors and retinoic acid play parallel roles in antero-posterior position of the pectoral fin field during gastrulation.Mechanisms of development · 2020Article
- Comparison of PLZF Gene Expression between Pluripotent Stem Cells and Testicular Germ Cells.Cell journal · 2020Article
- Pigeon foot feathering reveals conserved limb identity networks.Developmental biology · 2019Article
- Cux2 refines the forelimb field by controlling expression ofBiology open · 2019Article
- Timed Collinear Activation of Hox Genes during Gastrulation Controls the Avian Forelimb Position.Current biology : CB · 2019Article
- Article
- HOXA5 protein expression and genetic fate mapping show lineage restriction in the developing musculoskeletal system.The International journal of developmental biology · 2018Article
- Transcriptional changes in chick wing bud polarization induced by retinoic acid.Developmental dynamics : an official publication of the American Association of Anatomists · 2017Article
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Authors and funding
9 authors at 5 institutions in 3 countries.
Funding
Abstract
To date, only the five most posterior groups of Hox genes, Hox9-Hox13, have demonstrated loss-of-function roles in limb patterning. Individual paralog groups control proximodistal patterning of the limb skeletal elements. Hox9 genes also initiate the onset of Hand2 expression in the posterior forelimb compartment, and collectively, the posterior HoxA/D genes maintain posterior Sonic Hedgehog (Shh) expression. Here we show that an anterior Hox paralog group, Hox5, is required for forelimb anterior patterning. Deletion of all three Hox5 genes (Hoxa5, Hoxb5, and Hoxc5) leads to anterior forelimb defects resulting from derepression of Shh expression. The phenotype requires the loss of all three Hox5 genes, demonstrating the high level of redundancy in this Hox paralogous group. Further analyses reveal that Hox5 interacts with promyelocytic leukemia zinc finger biochemically and genetically to restrict Shh expression. These findings, along with previous reports showing that point mutations in the Shh limb enhancer lead to similar anterior limb defects, highlight the importance of Shh repression for proper patterning of the vertebrate limb.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.