ArticleProceedings of the National Academy of Sciences of the United States of America2013
Fungal-derived semiochemical 1-octen-3-ol disrupts dopamine packaging and causes neurodegeneration.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
38 citing papers in PubMed, 92 citations in OpenAlex.
- Differential modulation of feedforward inhibition reflects topographic organization in the olfactory system.Nature communications · 2025Article
- Toll-1-dependent immune evasion induced by fungal infection leads to cell loss in the Drosophila brain.PLoS biology · 2025Article
- From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences.Molecular neurobiology · 2025Review
- Diversity and functions of fungal VOCs with special reference to the multiple bioactivities of the mushroom alcohol.Mycology · 2025Review
- Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration.Environment international · 2023Article
- Anti-Insect Properties ofMicroorganisms · 2023Review
- Differential effects of exposure to toxic or nontoxic mold spores on brain inflammation and Morris water maze performance.Behavioural brain research · 2023Article
- Mutational Analysis ofJournal of fungi (Basel, Switzerland) · 2023Article
- A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone.Science advances · 2023Article
- 1-Octen-3-ol is formed from its primeveroside after mechanical wounding of soybean leaves.Plant molecular biology · 2022Article
- In Vitro Systems for Toxicity Evaluation of Microbial Volatile Organic Compounds on Humans: Current Status and Trends.Journal of fungi (Basel, Switzerland) · 2022Review
- Sugarcane multitrophic interactions: Integrating belowground and aboveground organisms.Genetics and molecular biology · 2022Article
- Genomic Analyses ofJournal of fungi (Basel, Switzerland) · 2021Article
- Genetic or Toxicant-Induced Disruption of Vesicular Monoamine Storage and Global Metabolic Profiling in Caenorhabditis elegans.Toxicological sciences : an official journal of the Society of Toxicology · 2021Article
- Highly sensitive VOC detectors using insect olfactory receptors reconstituted into lipid bilayers.Science advances · 2021Article
- Vesicular neurotransmitter transporters in Drosophila melanogaster.Biochimica et biophysica acta. Biomembranes · 2020Review
- Nutrition and Lifestyle Interventions for Managing Parkinson's Disease: A Narrative Review.Journal of movement disorders · 2020Article
- Volatile Organic Compounds Produced by Human Pathogenic Fungi Are Toxic toFrontiers in fungal biology · 2020Article
- Volatilomes of Bacterial Infections in Humans.Frontiers in neuroscience · 2020Review
- Influence of R and S enantiomers of 1-octen-3-ol on gene expression of Penicillium chrysogenum.Journal of industrial microbiology & biotechnology · 2019Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Parkinson disease (PD) is the most common movement disorder and, although the exact causes are unknown, recent epidemiological and experimental studies indicate that several environmental agents may be significant risk factors. To date, these suspected environmental risk factors have been man-made chemicals. In this report, we demonstrate via genetic, biochemical, and immunological studies that the common volatile fungal semiochemical 1-octen-3-ol reduces dopamine levels and causes dopamine neuron degeneration in Drosophila melanogaster. Overexpression of the vesicular monoamine transporter (VMAT) rescued the dopamine toxicity and neurodegeneration, whereas mutations decreasing VMAT and tyrosine hydroxylase exacerbated toxicity. Furthermore, 1-octen-3-ol also inhibited uptake of dopamine in human cell lines expressing the human plasma membrane dopamine transporter (DAT) and human VMAT ortholog, VMAT2. These data demonstrate that 1-octen-3-ol exerts toxicity via disruption of dopamine homeostasis and may represent a naturally occurring environmental agent involved in parkinsonism.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.