ArticleProceedings of the National Academy of Sciences of the United States of America2013
Growth hormone prevents the development of autoimmune diabetes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 32 citations in OpenAlex.
- Growth Hormone Administration Improves Nonalcoholic Fatty Liver Disease in Overweight/Obesity: A Randomized Trial.The Journal of clinical endocrinology and metabolism · 2023Trial
- Growth hormone restrains inflammatory activity of microglia/macrophages in CNS autoimmunity.Frontiers in cellular neuroscience · 2026Article
- Regression from stage 3 to stage 2 type 1 diabetes mellitus after discontinuing growth hormone therapy.Endocrinology, diabetes & metabolism case reports · 2023Article
- Growth hormone remodels the 3D-structure of the mitochondria of inflammatory macrophages and promotes metabolic reprogramming.Frontiers in immunology · 2023Article
- Growth Hormone and Insulin-Like Growth Factor 1 Regulation of Nonalcoholic Fatty Liver Disease.The Journal of clinical endocrinology and metabolism · 2022 · on this mapReview
- The Role of Chicken Prolactin, Growth Hormone and Their Receptors in the Immune System.Frontiers in microbiology · 2022Review
- Obesity and its impact on COVID-19.Journal of molecular medicine (Berlin, Germany) · 2021Review
- Is Growth Hormone Insufficiency the Missing Link Between Obesity, Male Gender, Age, and COVID-19 Severity?Obesity (Silver Spring, Md.) · 2020Article
- A Novel Mutation in Insulin-Like Growth Factor 1 Receptor (c.641-2A>G) Is Associated with Impaired Growth, Hypoglycemia, and Modified Immune Phenotypes.Hormone research in paediatrics · 2020Article
- Growth hormone-mediated reprogramming of macrophage transcriptome and effector functions.Scientific reports · 2019Article
- Dexamethasone during pregnancy impairs maternal pancreatic β-cell renewal during lactation.Endocrine connections · 2019Article
- Interactions Between the Neuroendocrine System and T Lymphocytes in Diabetes.Frontiers in endocrinology · 2018Review
- Inhibitory Role of Growth Hormone in the Induction and Progression Phases of Collagen-Induced Arthritis.Frontiers in immunology · 2018Article
- Growth hormone treatment of premature ovarian failure in a mouse model via stimulation of the Notch-1 signaling pathway.Experimental and therapeutic medicine · 2016Article
- Beneficial effects of growth hormone-releasing hormone agonists on rat INS-1 cells and on streptozotocin-induced NOD/SCID mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Recombinant human growth hormone in treatment of diabetes: report of three cases and review of relative literature.International journal of clinical and experimental medicine · 2015Article
- The Relationship between Metabolic Control and Growth in Children with Type I Diabetes Mellitus in Southwest of Iran.Scientifica · 2015Article
- The role of macrophage polarization in infectious and inflammatory diseases.Molecules and cells · 2014Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Evidence supports a relationship between the neuroendocrine and the immune systems. Data from mice that overexpress or are deficient in growth hormone (GH) indicate that GH stimulates T and B-cell proliferation and Ig synthesis, and enhances maturation of myeloid progenitor cells. The effect of GH on autoimmune pathologies has nonetheless been little studied. Using a murine model of type 1 diabetes, a T-cell-mediated autoimmune disease characterized by immune cell infiltration of pancreatic islets and destruction of insulin-producing β-cells, we observed that sustained GH expression reduced prodromal disease symptoms and eliminated progression to overt diabetes. The effect involves several GH-mediated mechanisms; GH altered the cytokine environment, triggered anti-inflammatory macrophage (M2) polarization, maintained activity of the suppressor T-cell population, and limited Th17 cell plasticity. In addition, GH reduced apoptosis and/or increased the proliferative rate of β-cells. These results support a role for GH in immune response regulation and identify a unique target for therapeutic intervention in type 1 diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.