ArticleProceedings of the National Academy of Sciences of the United States of America2013
FtsK-dependent XerCD-dif recombination unlinks replication catenanes in a stepwise manner.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 75 citations in OpenAlex.
- Topo IV is required to allow replisomes to converge and complete replication on the chromosome.PLoS genetics · 2025Article
- Spatio-temporal organization of theEcoSal Plus · 2024Review
- Investigating the mechanism of rough phenotype in a naturally attenuatedFrontiers in medicine · 2024Article
- Plasticity in the cell division processes of obligate intracellular bacteria.Frontiers in cellular and infection microbiology · 2023Review
- A dicentric bacterial chromosome requires XerC/D site-specific recombinases for resolution.Current biology : CB · 2022Article
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- DNA-Topology Simplification by Topoisomerases.Molecules (Basel, Switzerland) · 2021Review
- XerD unloads bacterial SMC complexes at the replication terminus.Molecular cell · 2021Article
- Functional Analysis of theAntibiotics (Basel, Switzerland) · 2020Article
- Loop-closure kinetics reveal a stable, right-handed DNA intermediate in Cre recombination.Nucleic acids research · 2020Article
- A topological analysis of difference topology experiments of condensin with topoisomerase II.Biology open · 2020Article
- The Rabl configuration limits topological entanglement of chromosomes in budding yeast.Scientific reports · 2019Article
- Kinetic pathways of topology simplification by Type-II topoisomerases in knotted supercoiled DNA.Nucleic acids research · 2019Article
- Pathways of DNA unlinking: A story of stepwise simplification.Scientific reports · 2017Article
- Knots cascade detected by a monotonically decreasing sequence of values.Scientific reports · 2016Article
- Assembly, translocation, and activation of XerCD-dif recombination by FtsK translocase analyzed in real-time by FRET and two-color tethered fluorophore motion.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Conservation of writhe helicity under anti-parallel reconnection.Scientific reports · 2015Article
- Free-energy calculations for semi-flexible macromolecules: applications to DNA knotting and looping.The Journal of chemical physics · 2014Article
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5 authors at 5 institutions in 4 countries.
Funding
Abstract
In Escherichia coli, complete unlinking of newly replicated sister chromosomes is required to ensure their proper segregation at cell division. Whereas replication links are removed primarily by topoisomerase IV, XerC/XerD-dif site-specific recombination can mediate sister chromosome unlinking in Topoisomerase IV-deficient cells. This reaction is activated at the division septum by the DNA translocase FtsK, which coordinates the last stages of chromosome segregation with cell division. It has been proposed that, after being activated by FtsK, XerC/XerD-dif recombination removes DNA links in a stepwise manner. Here, we provide a mathematically rigorous characterization of this topological mechanism of DNA unlinking. We show that stepwise unlinking is the only possible pathway that strictly reduces the complexity of the substrates at each step. Finally, we propose a topological mechanism for this unlinking reaction.
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