ArticleProceedings of the National Academy of Sciences of the United States of America2013
Genetic variants related to gap junctions and hormone secretion influence conception rates in cows.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 37 citations in OpenAlex.
- Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins.Scientific reports · 2017Pooled it
- Orchestrating epigenetics: a comprehensive review of the methyltransferase SETD6.Experimental & molecular medicine · 2025Review
- Genome-wide scan for signatures of selection in Hanwoo and Angus cattle using whole-genome sequence data.PloS one · 2025Article
- Genome-wide association studies of egg production traits by whole genome sequencing of Laiwu Black chicken.Poultry science · 2024Article
- Overexpression of Plakophilin2 Mitigates Capillary Leak Syndrome in Severe Acute Pancreatitis by Activating the p38/MAPK Signaling Pathway.Journal of inflammation research · 2024Article
- Transposon insertion profiling by sequencing (TIPseq) identifies novel LINE-1 insertions in human sperm.Journal of assisted reproduction and genetics · 2023Article
- A Post-GWAS Functional Analysis Confirming Effects of Three BTA13 GenesFrontiers in genetics · 2022Article
- Review
- Article
- Genetic Diversity and Signatures of Selection for Thermal Stress in Cattle and Other TwoFrontiers in genetics · 2021Article
- MicroRNAs from Extracellular Vesicles Secreted by Bovine Embryos as Early Biomarkers of Developmental Competence.International journal of molecular sciences · 2020Article
- Characterization and functional roles of paternal RNAs in 2-4 cell bovine embryos.Scientific reports · 2019Article
- Article
- Genomic and transcriptomic analyses reveal selection of genes for puberty in Bama Xiang pigs.Zoological research · 2018Article
- Genetic diversity and signatures of selection in various goat breeds revealed by genome-wide SNP markers.BMC genomics · 2017Article
- Genetic variants in the upstream region of activin receptor IIA are associated with female fertility in Japanese Black cattle.BMC genetics · 2015Article
- Stories and Challenges of Genome Wide Association Studies in Livestock - A Review.Asian-Australasian journal of animal sciences · 2015Article
- Molecular Effects of Polymorphism in the 3'UTR of Unc-5 homolog C Associated with Conception Rate in Holsteins.PloS one · 2015Article
- Abundance of gap junctions at glutamatergic mixed synapses in adult Mosquitofish spinal cord neurons.Frontiers in neural circuits · 2014Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The recent decline in fertility is a serious problem in the dairy industry. To overcome this problem, we performed a genome-wide association study using 384 Holsteins and identified four loci associated with conception rates. Two of them contained gap junction-related genes: PKP2 and CTTNBP2NL. Further analysis confirmed that PKP2 increased connexin 43, a gap junction protein, whereas CTTNBP2NL dephosphorylated connexin 43. Knockdown of PKP2 or overexpression of CTTNBP2NL inhibited embryo implantation in mice. The other two loci contained neuroendocrine-related genes: SETD6 and CACNB2. Additional experiments indicated that SETD6 is involved in the transcriptional regulation of gonadotropin-releasing hormone, whereas CACNB2 controlled the secretion of follicle-stimulating hormone in cattle. The total allele substitution effect of these genes on conception rate was 3.5%. Our findings reveal important roles for gap junction communication and the neuroendocrine system in conception and suggest unique selection methods to improve reproductive performance in the livestock industry.
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