ArticleThe Journal of infectious diseases2014
Effects of selective and nonselective nonsteroidal anti-inflammatory drugs on antibiotic efficacy of experimental group A streptococcal myonecrosis.
Article in The Journal of infectious diseases, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Nonsteroidal Anti-Inflammatory Drug without Antibiotics for Acute Viral Infection Increases the Empyema Risk in Children: A Matched Case-Control Study.The Journal of pediatrics · 2016Trial
- Inflammation-modulating agents in chronic limb-threatening ischemia: a narrative review of therapeutic potential and future directions.Annals of medicine and surgery (2012) · 2026Article
- The anti-inflammatory drug celecoxib is metabolized by Pseudomonas aeruginosa CYP107S1 in vitro and in vivo.Drug metabolism and disposition: the biological fate of chemicals · 2025Article
- Complicated and deep bacterial skin and soft tissue infections.Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG · 2025Review
- Group A Streptococcus interactions with the host across time and space.Current opinion in microbiology · 2024Review
- State of the Art of Invasive Group A Streptococcus Infection in Children: A Scoping Review of the Literature with a Focus on Predictors of Invasive Infection.Children (Basel, Switzerland) · 2023Article
- Opportunistic Invasive Infection by Group A Streptococcus During Anti-Interleukin-6 Immunotherapy.The Journal of infectious diseases · 2021Article
- Does anti-inflammatory drugs modify the severe odontogenic infection prognosis? A 10-year's experience.Medicina oral, patologia oral y cirugia bucal · 2021Observational
- Management of Infectious Emergencies for the Inpatient Dermatologist.Current dermatology reports · 2021Review
- Streptococcal toxic shock syndrome in the intensive care unit.Annals of intensive care · 2018Review
- Staphylococcus aureus produces pain through pore-forming toxins and neuronal TRPV1 that is silenced by QX-314.Nature communications · 2018Article
- Effect of non-steroidal anti-inflammatory drugs on post-surgical complications against the backdrop of the opioid crisis.Burns & trauma · 2018Review
- Effects of delayed NSAID administration after experimental eccentric contraction injury - A cellular and proteomics study.PloS one · 2017Article
- Prostaglandin E₂ constrains systemic inflammation through an innate lymphoid cell-IL-22 axis.Science (New York, N.Y.) · 2016Article
- The roles of injury and nonsteroidal anti-inflammatory drugs in the development and outcomes of severe group A streptococcal soft tissue infections.Current opinion in infectious diseases · 2015Review
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundEpidemiologic evidence suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) contribute to more severe group A streptococcal (GAS) infections, yet a beneficial role for NSAIDs has been demonstrated in other experimental bacterial infections.
methodsNonselective (ketorolac tromethamine, ibuprofen, indomethacin), COX-1-selective (SC-560), or COX-2-selective (SC-236) NSAIDs ± antibiotics (penicillin, clindamycin) were given to mice challenged intramuscularly with M-type 3 GAS and disease course was followed for 14 days. RESULTS. All nonselective NSAIDs significantly accelerated mortality and reduced antibiotic efficacy; COX-selective NSAIDs had no significant effects.
conclusionsUse of nonselective NSAIDs, either alone or as adjuncts to antibiotic therapy, for GAS soft tissue infection may contribute to worse outcomes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.