Evidence map›Paper›PMID 24218490›Full record

ArticlePlant physiology2014

Unequal redundancy in maize knotted1 homeobox genes.

Nathalie Bolduc, Randall G Tyers, Michael Freeling, Sarah Hake

Open access · hybridAbstract read
In one paragraph

Article in Plant physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Review
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  5. Review
  6. Article
  7. Trafficking and localization ofCommunicative & integrative biology · 2022
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  8. Improving architectural traits of maize inflorescences.Molecular breeding : new strategies in plant improvement · 2021
    Article
  9. Developmental genetics of maize vegetative shoot architecture.Molecular breeding : new strategies in plant improvement · 2021
    Article
  10. Article
  11. Expression of theFrontiers in plant science · 2017
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Nathalie BolducDepartment of Plant and Microbial Biology, University of California, Berkeley, California 94720.
Randall G Tyers
Michael Freeling
Sarah Hake
University of California, Berkeley · USAgricultural Research Service · USPlant Gene Expression Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The knotted1 (kn1) homeobox (knox) gene family was first identified through gain-of-function dominant mutants in maize (Zea mays). Class I knox members are expressed in meristems but excluded from leaves. In maize, a loss-of-function phenotype has only been characterized for kn1. To assess the function of another knox member, we characterized a loss-of-function mutation of rough sheath1 (rs1). rs1-mum1 has no phenotype alone but exacerbates several aspects of the kn1 phenotype. In permissive backgrounds in which kn1 mutants grow to maturity, loss of a single copy of rs1 enhances the tassel branch reduction phenotype, while loss of both copies results in limited shoots. In less introgressed lines, double mutants can grow to maturity but are shorter. Using a KNOX antibody, we demonstrate that RS1 binds in vivo to some of the KN1 target genes, which could partially explain why KN1 binds many genes but modulates few. Our results demonstrate an unequal redundancy between knox genes, with a role for rs1 only revealed in the complete absence of kn1.

Indexed as

Genes, HomeoboxGene Expression Regulation, PlantHomeodomain ProteinsMeristemMultigene FamilyMutationPhenotypePlant LeavesPlant ProteinsPlant ShootsZea maysHomeodomain ProteinsKn1 protein, plantPlant Proteins

Identifiers

PMID24218490
PMCPMC3875803
OpenAlexW1998659974

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.