ArticlePediatrics2013
Catheter dwell time and CLABSIs in neonates with PICCs: a multicenter cohort study.
Article in Pediatrics, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03730883 (The Effect of Early Versus Standard Central Line Removal on Growth of Very Low Birth Weight Premature Infants), which is not on this map. Cited by 63 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Effect of Early Versus Standard Central Line Removal on Growth of Very Low Birth Weight Premature Infants: A Non-inferiority, Randomized Controlled Trial
Who cites it
63 citing papers in PubMed, 8 syntheses or guidelines pooled it, 155 citations in OpenAlex.
- Comparative safety and effectiveness of midline catheters vs. peripherally inserted central catheters: a systematic review and meta-analysis.Frontiers in cardiovascular medicine · 2026Pooled it
- Risk factors for neonatal catheter-related bloodstream infections: a systematic review and meta-analysis.Frontiers in public health · 2025Pooled it
- Pooled it
- Efficacy of Antimicrobial-Impregnated Catheters for Prevention of Bloodstream Infections in Pediatric Patients: A Meta-Analysis.Frontiers in pediatrics · 2021Pooled it
- Taurolidine lock solution for catheter-related bloodstream infections in pediatric patients: A meta-analysis.PloS one · 2020Pooled it
- [Effect of placement of peripherally inserted central catheter via the upper versus lower extremity veins: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2019Pooled it
- Early planned removal versus expectant management of peripherally inserted central catheters to prevent infection in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Antibiotics at the time of removal of central venous catheter to reduce morbidity and mortality in newborn infants.The Cochrane database of systematic reviews · 2018Pooled it
- Influence of Parenteral Nutrition Delivery Techniques on Growth and Neurodevelopment of Very Low Birth Weight Newborns: A Randomized Trial.Medicina (Kaunas, Lithuania) · 2019Trial
- Prevention of neonatal late-onset sepsis: a randomised controlled trial.BMC pediatrics · 2017Trial
- Peripherally inserted central venous catheters: frequency of complications in premature newborn depends on the insertion site.Journal of perinatology : official journal of the California Perinatal Association · 2014Trial
- The impact of central venous catheter use on long-term growth and neurobehavioral outcome in preterm children born < 29 weeks of gestation.Molecular and cellular pediatrics · 2026Article
- Complications and risk factors of neonatal peripherally inserted central catheters lines.BMC pediatrics · 2026Article
- Enhancing neonatal vascular access: proposing a patient-centered framework based on 7-Rights.Pediatric research · 2026Article
- Inter-center variation in non-elective removal of central catheters amongst level 4 NICUs.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Temporal and anatomic determinants of central-line-associated bloodstream infection risk in a tertiary PICU: a 3-year time-to-event and competing-risk analysis.Frontiers in pediatrics · 2026Article
- Hospital-acquired infections in preterm infants with gestational age <32 weeks: a retrospective study of clinical characteristics, pathogen distribution, and associated factors.Frontiers in pediatrics · 2026Article
- Umbilical venous catheter and peripherally inserted central catheter malposition and tip migration in neonates: A mixed methods cost analysis.International journal of nursing studies advances · 2025Article
- The impact of central line-specific dwell-times for neonatal central line associated bloodstream infections.Antimicrobial resistance and infection control · 2025Article
- From colostomy creation to full enteral feeding in neonates with an anorectal malformation: evaluating the role of central venous access.Frontiers in surgery · 2025Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 9 institutions in 1 country.
Funding
Abstract
objectiveTo determine whether the daily risk of central line-associated bloodstream infections (CLABSIs) increases over the dwell time of peripherally inserted central catheters (PICCs) in high-risk neonates.
methodsMulticenter retrospective cohort including NICU patients with a PICC inserted between January 2005 and June 2010. We calculated incidence rates and used Poisson regression models to assess the risk of developing CLABSI as a function of PICC dwell time.
resultsA total of 4797 PICCs placed in 3967 neonates were included; 149 CLABSIs occurred over 89,946 catheter-days (incidence rate 1.66 per 1000 catheter-days). In unadjusted analysis, PICCs with a dwell time of 8 to 13 days, 14 to 22 days, and ≥23 days each had an increased risk of infection compared with PICCs in place for ≤7 days (P < .05). In adjusted analysis, the average predicted daily risk of CLABSIs after PICC insertion increased during the first 2 weeks after PICC insertion and remained elevated for the dwell time of the catheter. There was an increased risk of CLABSIs in neonates with concurrent PICCs (adjusted incidence rate ratio 2.04, 1.12-3.71). The incidence of Gram-negative CLABSIs was greater in PICCs with dwell times >50 days (incidence rate ratio 5.26, 2.40-10.66).
conclusionsThe risk of CLABSIs increased during the 2 weeks after PICC insertion and then remained elevated until PICC removal. Clinicians should review PICC necessity daily, optimize catheter maintenance practices, and investigate novel CLABSI prevention strategies in PICCs with prolonged dwell times.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.