ArticleCirculation2013
In utero diagnosis of long QT syndrome by magnetocardiography.
Article in Circulation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03775954 (Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Fetal Electrophysiologic Abnormalities in High-risk Pregnancies Associated With Fetal Demise
Who cites it
49 citing papers in PubMed, 1 synthesis or guideline pooled it, 113 citations in OpenAlex.
- Global trends and knowledge structure of cardiovascular magnetocardiography research: a bibliometric analysis.Frontiers in medicine · 2026Pooled it
- Fetal Magnetocardiography Using Optically Pumped Magnetometers: A Literature Review.Biosensors · 2026Review
- A Case of Fetal Bradycardia, or Not? Pulseless Ventricular Tachycardia in a Fetus with Congenital Long QT Syndrome.Pediatric cardiology · 2026Article
- Fetal magnetocardiography: Using quantum technologies to define fetal rhythm, conduction, and repolarization prior to birth.American heart journal plus : cardiology research and practice · 2025Article
- Fetal Conduction Disease and Arrhythmia in Ebstein's Anomaly and Tricuspid Valve Dysplasia Assessed by Fetal Magnetocardiography.Journal of the American Heart Association · 2025Observational
- A customized bed based stand alone array of optically pumped magnetometers for fetal magnetocardiography measurements.Scientific reports · 2025Article
- AI-enabled diagnosis and localization of myocardial ischemia and coronary artery stenosis from magnetocardiographic recordings.Scientific reports · 2025Article
- Advances of magnetocardiography in application of adult and fetal cardiac diseases.Frontiers in cardiovascular medicine · 2025Review
- The magnetocardiogram.Biophysics reviews · 2024Review
- Successful Management of Fetal Torsades de Pointes and Long QT Syndrome by a Cardio-Obstetrical Team.JACC. Case reports · 2023Article
- Effects of cohort, genotype, variant, and maternal β-blocker treatment on foetal heart rate predictors of inherited long QT syndrome.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023Article
- Fetal Heart Rate < 3rd Percentile for Gestational Age Can Be a Marker of Inherited Arrhythmia Syndromes.Journal of clinical medicine · 2023Article
- Rediscovery of magnetocardiography for diagnostic screening and monitoring of treatment response in cardiology.European heart journal · 2023Article
- A Small Scale Optically Pumped Fetal Magnetocardiography System.Journal of clinical medicine · 2023Article
- Preventing and Treating Torsades de Pointes in the Mother, Fetus and Newborn in the Highest Risk Pregnancies with Inherited Arrhythmia Syndromes.Journal of clinical medicine · 2023Review
- Application of Magnetocardiography to Screen for Inflammatory Cardiomyopathy and Monitor Treatment Response.Journal of the American Heart Association · 2023Article
- Fetal Bradycardia Caused by Monogenic Disorders-A Review of the Literature.Journal of clinical medicine · 2022Review
- Fetal Arrhythmia Diagnosis and Pharmacologic Management.Journal of clinical pharmacology · 2022Review
- Contribution of Fetal Magnetocardiography to Diagnosis, Risk Assessment, and Treatment of Fetal Arrhythmia.Journal of the American Heart Association · 2022Review
- Article
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 2 countries.
Funding
Abstract
backgroundThe electrophysiology of long QT syndrome (LQTS) in utero is virtually unstudied. Our goal here was to evaluate the efficacy of fetal magnetocardiography (fMCG) for diagnosis and prognosis of fetuses at risk of LQTS. METHODS AND
resultsWe reviewed the pre/postnatal medical records of 30 fetuses referred for fMCG because of a family history of LQTS (n=17); neonatal/childhood sudden cardiac death (n=3), or presentation of prenatal LQTS rhythms (n=12): 2° atrioventricular block, ventricular tachycardia, heart rate < 3(rd) percentile. We evaluated heart rate and reactivity, cardiac time intervals, T-wave characteristics, and initiation/termination of Torsade de Pointes, and compared these with neonatal ECG findings. After birth, subjects were tested for LQTS mutations. Based on accepted clinical criteria, 21 subjects (70%; 9 KCNQ1, 5 KCNH2, 2 SCN5A, 2 other, 3 untested) had LQTS. Using a threshold of corrected QT= 490 ms, fMCG accurately identified LQTS fetuses with 89% (24/27) sensitivity and 89% (8/9) specificity in 36 sessions. Four fetuses (2 KCNH2 and 2 SCN5A), all with corrected QT ≥ 620 ms, had frequent episodes of Torsade de Pointes, which were present 22-79% of the time. Although some episodes initiated with a long-short sequence, most initiations showed QRS aberrancy and a notable lack of pause dependency. T-wave alternans was strongly associated with severe LQTS phenotype.
conclusionsCorrected QT prolongation (≥490 ms) assessed by fMCG accurately identified LQTS in utero; extreme corrected QT prolongation (≥620 ms) predicted Torsade de Pointes. FMCG can play a critical role in the diagnosis and management of fetuses at risk of LQTS.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.