ArticleJournal of experimental botany2014
FLC-mediated flowering repression is positively regulated by sumoylation.
Article in Journal of experimental botany, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Article
- Retromer protein VPS29 plays a crucial and positive role in the sumoylation system mediated by E3 SUMO ligase SIZ1.The Plant journal : for cell and molecular biology · 2025Article
- Highly sensitive site-specific SUMOylation proteomics in Arabidopsis.Nature plants · 2024Article
- E3 SUMO ligase SIZ1 splicing variants localize and function according to external conditions.Plant physiology · 2024Article
- Flowering genes identification, network analysis, and database construction for 837 plants.Horticulture research · 2024Article
- Inhibition of SIZ1-mediated SUMOylation of HOOKLESS1 promotes light-induced apical hook opening in Arabidopsis.The Plant cell · 2023Article
- Article
- Ammonium-mediated reduction in salicylic acid content and recovery of plant growth in ArabidopsisPlant signaling & behavior · 2021Article
- Ectopic expression of LoSVP, a MADS-domain transcription factor from lily, leads to delayed flowering in transgenic Arabidopsis.Plant cell reports · 2020Article
- Single-molecule real-time transcript sequencing identified flowering regulatory genes in Crocus sativus.BMC genomics · 2019Article
- SUMO modification of LBD30 by SIZ1 regulates secondary cell wall formation in Arabidopsis thaliana.PLoS genetics · 2019Article
- Nitrate Reductases Are Relocalized to the Nucleus by AtSIZ1 and Their Levels Are Negatively Regulated by COP1 and Ammonium.International journal of molecular sciences · 2018Article
- Post-translational modifications of Arabidopsis E3 SUMO ligase AtSIZ1 are controlled by environmental conditions.FEBS open bio · 2017Article
- Research progress on the autonomous flowering time pathway inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2017Review
- ABSCISIC ACID-INSENSITIVE 4 negatively regulates flowering through directly promoting Arabidopsis FLOWERING LOCUS C transcription.Journal of experimental botany · 2016Article
- COP1 Controls Abiotic Stress Responses by Modulating AtSIZ1 Function through Its E3 Ubiquitin Ligase Activity.Frontiers in plant science · 2016Article
- Arabidopsis HIGH PLOIDY2 Sumoylates and Stabilizes Flowering Locus C through Its E3 Ligase Activity.Frontiers in plant science · 2016Article
- Functional characterization of DnSIZ1, a SIZ/PIAS-type SUMO E3 ligase from Dendrobium.BMC plant biology · 2015Article
- Interconnection between flowering time control and activation of systemic acquired resistance.Frontiers in plant science · 2015Review
- Arabidopsis PIAL1 and 2 promote SUMO chain formation as E4-type SUMO ligases and are involved in stress responses and sulfur metabolism.The Plant cell · 2014Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Flowering locus C (FLC), a floral repressor, is a critical factor for the transition from the vegetative to the reproductive phase. Here, the mechanisms regulating the activity and stability of the FLC protein were investigated. Bimolecular fluorescence complementation and in vitro pull-down analyses showed that FLC interacts with the E3 small ubiquitin-like modifier (SUMO) ligase AtSIZ1, suggesting that AtSIZ1 is an E3 SUMO ligase for FLC. In vitro sumoylation assays showed that FLC is modified by SUMO in the presence of SUMO-activating enzyme E1 and conjugating enzyme E2, but its sumoylation is inhibited by AtSIZ1. In transgenic plants, inducible AtSIZ1 overexpression led to an increase in the concentration of FLC and delayed the post-translational decay of FLC, indicating that AtSIZ1 stabilizes FLC through direct binding. Also, the flowering time in mutant FLC (K154R, a mutation of the sumoylation site)-overexpressing plants was comparable with that in the wild type, whereas flowering was considerably delayed in FLC-overexpressing plants, supporting the notion that sumoylation is an important mechanism for FLC function. The data indicate that the sumoylation of FLC is critical for its role in the control of flowering time and that AtSIZ1 positively regulates FLC-mediated floral suppression.
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