ArticleThe Journal of experimental medicine2013
The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response.
Article in The Journal of experimental medicine, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers.
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Who cites it
94 citing papers in PubMed, 161 citations in OpenAlex.
- Allergen-specific IgGThe Journal of allergy and clinical immunology · 2020Trial
- Allergic Sensitization to Inhalant Allergens in the Upper Respiratory Tract-the B Cell Side.Allergy · 2026Review
- Multiple roads to IgE memory: A pluralistic model of IgE immunity.Cell reports · 2026Review
- Mixed Signals: T Cells as Architects of IgE Immunity.Immunological reviews · 2026Review
- Comparison of dominant foodborne and inhalant allergies developing in the first 5 years of life.The World Allergy Organization journal · 2026Article
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- Article
- Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program.Immunity · 2025Article
- Allergic Reactivity and Memory Occur Independently of Sequential Switching Through IgG1.Allergy · 2025Article
- Advances in Food Allergy Immunotherapy: Current Strategies and Role of Antibodies Isotypes.Cells · 2025Review
- Maternal IgE Influence on Fetal and Infant Health.Immunological reviews · 2025Review
- Lung-resident memory B cells maintain allergic IgE responses in the respiratory tract.Immunity · 2025Article
- Polarization of the memory B-cell response.Journal of leukocyte biology · 2025Review
- Reprogramming human B cells with custom heavy-chain antibodies.Nature biomedical engineering · 2024Article
- All roads lead to IgA: Mapping the many pathways of IgA induction in the gut.Immunological reviews · 2024Review
- Whence and wherefore IgE?Immunological reviews · 2024Review
- Control of germinal center B cell survival and IgE production by an adaptor molecule containing PH and SH2 domains, Aps/Sh2b2.Scientific reports · 2024Article
- IgE and anaphylaxis specific to the carbohydrate alpha-gal depend on IL-4.The Journal of allergy and clinical immunology · 2024Article
- B cell memory: from generation to reactivation: a multipronged defense wall against pathogens.Cell death discovery · 2024Review
- CD23Science translational medicine · 2024Article
34 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE(+) cells in memory responses is particularly unclear. IgE(+) B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE(+) GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE(+) GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE(+) GC cells, whereas sequential switching gives rise to IgE(+) PCs. We propose a comprehensive model for the generation and memory of IgE responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.