ArticleExperimental brain research2014
Reciprocal interactions between the human thalamus and periaqueductal gray may be important for pain perception.
Article in Experimental brain research, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Modulation effects of different treatments on periaqueductal gray resting state functional connectivity in knee osteoarthritis knee pain patients.CNS neuroscience & therapeutics · 2023Trial
- Building up analgesia in humans via the endogenous μ-opioid system by combining placebo and active tDCS: a preliminary report.PloS one · 2014Trial
- Electroencephalography research in neuropathic pain (Review).Molecular medicine reports · 2026Review
- Article
- Hypoperfusion of periaqueductal gray as an imaging biomarker in chronic migraine beyond diagnosis: A 3D pseudocontinuous arterial spin labeling MR imaging.Brain and behavior · 2024Article
- Neuropathic pain in cats: Mechanisms and multimodal management.Journal of feline medicine and surgery · 2024Review
- Altered functional connectivity of brainstem nuclei in new daily persistent headache: Evidence from resting-state functional magnetic resonance imaging.CNS neuroscience & therapeutics · 2024Article
- The dual facilitatory and inhibitory effects of social pain on physical pain perception.iScience · 2024Article
- Structural and Physiological Modeling (SAPM) for the Analysis of Functional MRI Data Applied to a Study of Human Nociceptive Processing.Brain sciences · 2023Article
- [Towards a positive physiological definition of the deep brain nuclei in humans].Revista de neurologia · 2022Article
- Review
- Neurophysiological Characterization of Posteromedial Hypothalamus in Anaesthetized Patients.Brain sciences · 2021Article
- Activation of CamKIIα expressing neurons on ventrolateral periaqueductal gray improves behavioral hypersensitivity and thalamic discharge in a trigeminal neuralgia rat model.The journal of headache and pain · 2021Article
- Features of Action Potentials from Identified Thalamic Nuclei in Anesthetized Patients.Brain sciences · 2020Article
- Neurophysiological Characterization of Thalamic Nuclei in Epileptic Anaesthetized Patients.Brain sciences · 2019Article
- Developing an optimized strategy with transcranial direct current stimulation to enhance the endogenous pain control system in fibromyalgia.Expert review of medical devices · 2018Review
- Responsivity of Periaqueductal Gray Connectivity Is Related to Headache Frequency in Episodic Migraine.Frontiers in neurology · 2018Article
- Insights into the mechanisms of deep brain stimulation.Nature reviews. Neurology · 2017Review
- Neuropathic pain and deep brain stimulation.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2014Review
- Effect of spinal manipulation thrust magnitude on trunk mechanical activation thresholds of lateral thalamic neurons.Journal of manipulative and physiological therapeutics · 2014Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pain perception can be altered by activity in the periaqueductal gray (PAG). The PAG can decrease the incoming nociceptive signals at the level of the spinal dorsal horn, but it is not clear whether the PAG can also affect the sensory thalamus, ventral posterolateral and ventral posteromedial thalamic nuclei, to modulate pain. However, the PAG and the thalamus have direct connections with each other; so we postulated that the PAG may also modulate pain by inhibiting the sensory nuclei in the thalamus, and that these may also reciprocally influence the PAG. Here, by analyzing the local field potentials recorded from the sensory thalamus and the PAG in chronic pain patients with deep brain stimulation electrodes, we show that PAG stimulation inhibited the sensory thalamus with decreasing thalamic delta, theta, alpha and beta power, and sensory thalamus stimulation excited the PAG with increasing PAG delta and theta power. We demonstrate that the PAG and the sensory thalamus interact reciprocally at short latency, which may be related to pain modulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.