ArticleInternational urology and nephrology2014
Membranous glomerulonephritis with crescents.
Article in International urology and nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.
- Diagnostic accuracy of PLA2R autoantibodies and glomerular staining for the differentiation of idiopathic and secondary membranous nephropathy: an updated meta-analysis.Scientific reports · 2015Pooled it
- Analysis of glucocorticoid receptor and microRNAs expression in pathological renal tissues.Molecular medicine reports · 2023Article
- Anti-Phospholipase A2 Receptor in Nonlupus Patients with Membranous Nephropathy and Crescents.Glomerular diseases · 2022Article
- The Role of Parietal Epithelial Cells in the Pathogenesis of Podocytopathy.Frontiers in physiology · 2022Review
- Membranous Glomerulonephritis With Crescents.Kidney international reports · 2019Article
- Role of the glucocorticoid receptor in glomerular disease.American journal of physiology. Renal physiology · 2019Review
- Clinicopathological and long-term prognostic features of membranous nephropathy with crescents: a Japanese single-center experience.Clinical and experimental nephrology · 2018Article
- Renal pathology in hematopoietic cell transplant recipients: a contemporary biopsy, nephrectomy, and autopsy series.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- Anti-Phospholipase AImmunology, endocrine & metabolic agents in medicinal chemistry · 2016Article
- Crescentic glomerulonephritis and membranous nephropathy: a rare coexistence.International urology and nephrology · 2015Article
- Study of mizoribine therapy in elderly patients with membranous nephropathy: comparison with patients not receiving mizoribine.International urology and nephrology · 2015Article
- New insights into glomerular parietal epithelial cell activation and its signaling pathways in glomerular diseases.BioMed research international · 2015Review
- Membranous nephropathy with crescents in a patient with Hashimoto's thyroiditis: a case report.Medicine · 2014Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe coexistence of membranous glomerulonephritis (MGN) and necrotizing and crescentic glomerulonephritis (NCGN) is an unusual finding in a renal biopsy except in lupus nephritis. Little is known about whether these lesions are causally related in any clinical setting.
methodsWe reviewed the pathology, presentation, and clinical course of 13 non-lupus patients with combined MGN and NCGN in native kidney biopsies (nine females, four males; median age 69 years), with particular attention to evidence of secondary MGN. Additional IgG subclass and phospholipase A2 receptor (PLA2R) immunofluorescence studies were conducted in seven cases.
resultsEight biopsies were pauci-immune other than the capillary wall deposits of MGN; one patient had a non-lupus immune complex disease, and four had mesangial deposits, including one with rare subendothelial deposits. None had anti-glomerular basement membrane disease. IgG4 was dominant or codominant in the capillary wall deposits in three cases and virtually absent in four; PLA2R was positive in two cases, and negative in five. Seven patients were judged to have secondary MGN, including five of eight ANCA+ patients. Twelve patients were treated with combinations of steroids, cyclophosphamide, rituximab, followed by durable response in seven and relentless progression to end stage renal disease in four.
conclusionsSecondary MGN occurs with higher frequency in ANCA-positive NCGN than in the general MGN population. A causal relationship between MGN and NCGN was not established in any patient, but circumstances suggest a common cause in several, including immune complex disease, drug reaction and paraneoplastic syndrome.
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