ReviewPediatric nephrology (Berlin, Germany)2014
The interplay between drugs and the kidney in premature neonates.
Review in Pediatric nephrology (Berlin, Germany), 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- The Long-Term Effect of Preterm Birth on Renal Function: A Meta-Analysis.International journal of environmental research and public health · 2021Pooled it
- Developmental origins and environmental determinants of cardiovascular-kidney-metabolic syndrome: A pediatric precision prevention perspective.Biomedical journal · 2026Review
- Maternal nutrition can rapidly rescue a nephron deficit in low birthweight offspring.npj metabolic health and disease · 2025Article
- Early Detection of Acute Kidney Injury After Congenital Heart Surgery-Using Urine Proteomics to Identify New Biomarker Candidates: A Prospective Clinical Study.Journal of clinical medicine · 2025Article
- Neonatal Kidney Function, Injury and Drug Dosing: A Contemporary Review.Children (Basel, Switzerland) · 2025Review
- Personalized application of antimicrobial drugs in pediatric patients with augmented renal clearance: a review of literature.European journal of pediatrics · 2024Review
- The Urinary Concentrations of Neutrophil Gelatinase-Associated Lipocalin, Cystatin C and Osteopontin in the Healthy Term and Stable Preterm Neonates: A Pilot Study.Journal of clinical medicine · 2023Article
- Current knowledge, challenges and innovations in developmental pharmacology: A combined conect4children Expert Group and European Society for Developmental, Perinatal and Paediatric Pharmacology White Paper.British journal of clinical pharmacology · 2022Review
- Prediction of glomerular filtration rate maturation across preterm and term neonates and young infants using inulin as marker.The AAPS journal · 2022Article
- Drug Clearance in Neonates: A Combination of Population Pharmacokinetic Modelling and Machine Learning Approaches to Improve Individual Prediction.Clinical pharmacokinetics · 2021Article
- Maturation of glomerular filtration rate in neonates and infants: an overview.Pediatric nephrology (Berlin, Germany) · 2021Review
- Shaping of the nephron - a complex, vulnerable, and poorly explored backdrop for noxae impairing nephrogenesis in the fetal human kidney.Molecular and cellular pediatrics · 2020Article
- Augmented renal clearance in pediatric intensive care: are we undertreating our sickest patients?Pediatric nephrology (Berlin, Germany) · 2020Review
- Renal Precision Medicine in Neonates and Acute Kidney Injury: How to Convert a Cloud of Creatinine Observations to Support Clinical Decisions.Frontiers in pediatrics · 2020Review
- Efficacy and Safety of Intravenous Colistin in Very Low Birth Weight Preterm Infants.Paediatric drugs · 2018Article
- Pharmacokinetics of Penicillin G in Preterm and Term Neonates.Antimicrobial agents and chemotherapy · 2018Article
- Neonatal drug therapy: The first frontier of therapeutics for children.Clinical pharmacology and therapeutics · 2015Review
- Drug-induced renal damage in preterm neonates: state of the art and methods for early detection.Drug safety · 2015Review
- Use of non-conventional biomarkers in the early diagnosis of acute kidney injury in preterm newborns with sepsis.Jornal brasileiro de nefrologiaReview
- Glomerular Filtration Rate Estimation Formulas for Pediatric and Neonatal Use.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAGReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The kidney plays a central role in the clearance of drugs. However, renal drug handling entails more than glomerular filtration and includes tubular excretion and reabsorption, and intracellular metabolization by cellular enzyme systems, such as the Cytochrome P450 isoenzymes. All these processes show maturation from birth onwards, which is one of the reasons why drug dosing in children is not simply similar to dosing in small adults. As kidney development normally finishes around the 36th week of gestation, being born prematurely will result in even more immature renal drug handling. Environmental effects, such as extra-uterine growth restriction, sepsis, asphyxia, or drug treatments like caffeine, aminoglycosides, or non-steroidal anti-inflammatory drugs, may further hamper drug handling in the kidney. Dosing in preterm neonates is therefore dependent on many factors that need to be taken into account. Drug treatment may significantly hamper postnatal kidney development in preterm neonates, just like renal immaturity has an impact on drug handling. The restricted kidney development results in a lower number of nephrons that may have several long-term sequelae, such as hypertension, albuminuria, and renal failure. This review focuses on the interplay between drugs and the kidney in premature neonates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.