ArticleAntimicrobial agents and chemotherapy2014
In vitro study of sequential fluconazole and caspofungin treatment against Candida albicans biofilms.
Article in Antimicrobial agents and chemotherapy, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 36 citations in OpenAlex.
- Thermoresponsive carbohydrate polymer mucoadhesive gel for synergistic delivery of acarbose and fluconazole against Candida biofilms.Scientific reports · 2026Article
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- Synergic Effect of the Antimicrobial Peptide ToAP2 and Fluconazole onInternational journal of molecular sciences · 2024Article
- Candida albicans and Antifungal Peptides.Infectious diseases and therapy · 2023Article
- Fingolimod Potentiates the Antifungal Activity of Amphotericin B.Frontiers in cellular and infection microbiology · 2021Article
- Fluconazole conjugated-gold nanorods as an antifungal nanomedicine with low cytotoxicity against human dermal fibroblasts.RSC advances · 2020Article
- Promising Therapeutic Strategies Against Microbial Biofilm Challenges.Frontiers in cellular and infection microbiology · 2020Review
- The Synergism of the Small Molecule ENOblock and Fluconazole Against Fluconazole-ResistantFrontiers in microbiology · 2019Article
- Antifungal effects of indolicidin-conjugated gold nanoparticles against fluconazole-resistant strains ofInternational journal of nanomedicine · 2019Article
- Cinnamaldehyde, a Promising Natural Preservative AgainstFrontiers in microbiology · 2019Article
- Review
- New facets of antifungal therapy.Virulence · 2017Review
- Screening the Pathogen Box for Identification of Candida albicans Biofilm Inhibitors.Antimicrobial agents and chemotherapy · 2017Article
- Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance ofFrontiers in cellular and infection microbiology · 2017Article
- Article
- Synergistic Effects and Mechanisms of Budesonide in Combination with Fluconazole against Resistant Candida albicans.PloS one · 2016Article
- From Biology to Drug Development: New Approaches to Combat the Threat of Fungal Biofilms.Microbiology spectrum · 2015Article
- Quercetin sensitizes fluconazole-resistant candida albicans to induce apoptotic cell death by modulating quorum sensing.Antimicrobial agents and chemotherapy · 2015Article
- Nylon-3 polymers active against drug-resistant Candida albicans biofilms.Journal of the American Chemical Society · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Candida albicans biofilms are generally considered to be resistant to azole antifungal agents but susceptible to echinocandins. We demonstrate that in a sequential therapy regimen, treatment with fluconazole first followed by caspofungin leads to a significant decrease of the efficacy of this echinocandin. Cellular stress responses induced by high fluconazole concentrations and mediated by Hsp90 and calcineurin play an important role in this phenomenon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.