ReviewNature reviews. Nephrology2014
Fluid management for the prevention and attenuation of acute kidney injury.
Review in Nature reviews. Nephrology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 8 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
133 citing papers in PubMed, 8 syntheses or guidelines pooled it, 329 citations in OpenAlex.
- Factors associated with postoperative acute kidney injury in stanford type a aortic dissection in china: a systematic review and meta-analysis.Journal of cardiothoracic surgery · 2026Pooled it
- Pooled it
- Comparison of Different Furosemide Regimens in the Treatment of Acute Heart Failure: A Meta-Analysis.Computational and mathematical methods in medicine · 2022Pooled it
- Continuous versus intermittent administration of furosemide in acute decompensated heart failure: a systematic review and meta-analysis.Heart failure reviews · 2019Pooled it
- Intermittent furosemide administration in patients with or at risk for acute kidney injury: Meta-analysis of randomized trials.PloS one · 2018Pooled it
- Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 : Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine.Intensive care medicine · 2017Pooled it
- Passive leg raising for predicting fluid responsiveness: a systematic review and meta-analysis.Intensive care medicine · 2016Pooled it
- [New KDIGO guidelines on acute kidney injury. Practical recommendations].Der Anaesthesist · 2014Guideline
- Beverage-Specific Modulation of Urinary Inflammatory Biomarkers After Endurance Running in Trained Males.Nutrients · 2025Trial
- Development and validation of a predictive model for acute kidney injury in patients with moderately severe and severe acute pancreatitis.Clinical and experimental nephrology · 2022Trial
- Restrictive fluid management versus usual care in acute kidney injury (REVERSE-AKI): a pilot randomized controlled feasibility trial.Intensive care medicine · 2021Trial
- Machine learning phenotypes and heterogeneous albumin effects in cirrhotic AKI: a causal inference study.Internal and emergency medicine · 2026Article
- Ventilator-Associated Pneumonia: The Role of Kidney-Lung Crosstalk and Renal Replacement Therapy, a Narrative Review.Journal of clinical medicine · 2026Review
- SMTP-44D Attenuates Renal Inflammatory/Oxidative Dysfunction in a Mouse Model of Ischemia-Reperfusion-Induced Acute Kidney Injury.International journal of molecular sciences · 2026Article
- Implementation of the kidney protection strategy in critically ill patients with acute kidney injury - a multi-center prospective cohort study.Critical care (London, England) · 2026Article
- Comments on: "Dexmedetomidine reduces acute kidney injury in high-risk but not low-risk patients after non-cardiac surgery: secondary analysis of a randomized controlled trial".Journal of anesthesia · 2026Article
- Restrictive nutrition in shock: reassuring renal signals-but no proof of safety.Intensive care medicine · 2026Article
- Clinical Profile and Survival Outcomes of Children with Acute Kidney Injury Requiring Renal Replacement Therapy: A Retrospective Study from a Tertiary Pediatric Intensive Care Unit.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2026Article
- How to perform fluid de-escalation in critical care.Annals of intensive care · 2026Review
- Professor Rinaldo Bellomo: Founder, architect, and choreographer of critical care nephrology.Critical care and resuscitation : journal of the Australasian Academy of Critical Care Medicine · 2025Review
73 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In patients with acute kidney injury (AKI), optimization of systemic haemodynamics is central to the clinical management. However, considerable debate exists regarding the efficacy, nature, extent and duration of fluid resuscitation, particularly when the patient has undergone major surgery or is in septic shock. Crucially, volume resuscitation might be required to maintain or restore cardiac output. However, resultant fluid accumulation and tissue oedema can substantially contribute to ongoing organ dysfunction and, particularly in patients developing AKI, serious clinical consequences. In this Review, we discuss the conflict between the desire to achieve adequate resuscitation of shock and the need to mitigate the harmful effects of fluid overload. In patients with AKI, limiting and resolving fluid overload might prompt earlier use of renal replacement therapy. However, rapid or early excessive fluid removal with diuretics or extracorporeal therapy might lead to hypovolaemia and recurrent renal injury. Optimal management might involve a period of guided fluid resuscitation, followed by management of an even fluid balance and, finally, an appropriate rate of fluid removal. To obtain best clinical outcomes, serial fluid status assessment and careful definition of cardiovascular and renal targets will be required during fluid resuscitation and removal.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.