ArticleMarine drugs2013
Crambescidin-816 acts as a fungicidal with more potency than crambescidin-800 and -830, inducing cell cycle arrest, increased cell size and apoptosis in Saccharomyces cerevisiae.
Article in Marine drugs, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- Sphaeropsidin A Loaded in Liposomes to Reduce Its Cytotoxicity and Preserve Antifungal Activity AgainstMolecules (Basel, Switzerland) · 2024Article
- Marine-Derived Anticancer Agents Targeting Apoptotic Pathways: Exploring the Depths for Novel Cancer Therapies.Marine drugs · 2024Review
- Polyphenol-Capped Biogenic Synthesis of Noble Metallic Silver Nanoparticles for Antifungal Activity againstJournal of fungi (Basel, Switzerland) · 2022Article
- Comprehensive Virtual Screening of the Antiviral Potentialities of Marine Polycyclic Guanidine Alkaloids against SARS-CoV-2 (COVID-19).Biomolecules · 2021Article
- Phytogenic Fabrication of Ag-Fe Bimetallic Nanoparticles for Cell Cycle Arrest and Apoptosis Signaling Pathways inAntioxidants (Basel, Switzerland) · 2021Article
- Facile Bio-Fabrication of Ag-Cu-Co Trimetallic Nanoparticles and Its Fungicidal Activity againstJournal of fungi (Basel, Switzerland) · 2021Article
- Crambescin C1 Acts as A Possible Substrate of iNOS and eNOS Increasing Nitric Oxide Production and InducingFrontiers in pharmacology · 2021Article
- Review
- Long-term experimentalPeerJ · 2018Article
- The Oxepane Motif in Marine Drugs.Marine drugs · 2017Review
- Review
- How Environmental Factors Affect the Production of Guanidine Alkaloids by the Mediterranean Sponge Crambe crambe.Marine drugs · 2017Article
- Structure, synthesis and biological properties of the pentacyclic guanidinium alkaloids.Bioorganic & medicinal chemistry · 2017Review
- Article
- Guanidine Alkaloids from the Marine Sponge Monanchora pulchra Show Cytotoxic Properties and Prevent EGF-Induced Neoplastic Transformation in Vitro.Marine drugs · 2016Article
- Spherulization as a process for the exudation of chemical cues by the encrusting sponge C. crambe.Scientific reports · 2016Article
- Polycyclic Guanidine Alkaloids from Poecilosclerida Marine Sponges.Marine drugs · 2016Review
- Crambescin C1 Exerts a Cytoprotective Effect on HepG2 Cells through Metallothionein Induction.Marine drugs · 2015Article
- Syntheses of Cyclic Guanidine-Containing Natural Products.Tetrahedron · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this paper, we show the effect of crambescidin-816, -800, and -830 on Saccharomyces cerevisiae viability. We determined that, of the three molecules tested, crambescidin-816 was the most potent. Based on this result, we continued by determining the effect of crambescidin-816 on the cell cycle of this yeast. The compound induced cell cycle arrest in G2/M followed by an increase in cell DNA content and size. When the type of cell death was analyzed, we observed that crambescidin-816 induced apoptosis. The antifungal effect indicates that crambescidins, and mostly crambescidin-816, could serve as a lead compound to fight fungal infections.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.