Evidence map›Paper›PMID 24217154›Full record

ArticleLeukemia2014

The tumor suppressor axis p53/miR-34a regulates Axl expression in B-cell chronic lymphocytic leukemia: implications for therapy in p53-defective CLL patients.

J Boysen, S Sinha, T Price-Troska, S L Warner, D J Bearss, D Viswanatha, T D Shanafelt, N E Kay, A K Ghosh

Open access · greenAbstract readLetter
In one paragraph

Article in Leukemia, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
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  8. Review
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  13. miRNAs in Normal and Malignant Hematopoiesis.International journal of molecular sciences · 2017
    Review
  14. Article
  15. Review
  16. Review
  17. Aberrant microRNA expression in tumor mycosis fungoides.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016
    Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

J BoysenDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
S SinhaDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
T Price-TroskaDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
S L WarnerTolero Pharmaceuticals Inc., Salt Lake City, UT, USA.
D J BearssTolero Pharmaceuticals Inc., Salt Lake City, UT, USA.
D ViswanathaDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
T D ShanafeltDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
N E KayDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
A K GhoshDivision of Hematology, Mayo Clinic, Rochester, MN, USA.
Mayo Clinic in Arizona · USTolero Pharmaceuticals (United States) · US

Funding

Combination Therapy in B-Chronic Lymphocytic LeukemiaR01CA095241 · NCI · MAYO CLINIC ROCHESTER · PI KAY, NEIL E · 2002 to 2012
$5.7M
Microvesicle Dynamics in B-Cell Chronic Lymphocytic Leukemia Tumor MicroenvironmeR01CA170006 · NCI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI GHOSH, ASISH KUMAR · 2013 to 2017
$1.6M
NCI NIH HHS CA170006-01A1NCI NIH HHS CA95241NCI NIH HHS R01 CA095241NCI NIH HHS R01 CA170006
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Gene Expression Regulation, Leukemic3' Untranslated RegionsAxl Receptor Tyrosine KinaseHumansLeukemia, Lymphocytic, Chronic, B-CellMicroRNAsMolecular Targeted TherapyProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesRNA InterferenceTumor Suppressor Protein p533' Untranslated RegionsAXL protein, humanAxl Receptor Tyrosine KinaseMicroRNAsMIRN34 microRNA, humanProto-Oncogene ProteinsReceptor Protein-Tyrosine KinasesTumor Suppressor Protein p53

Identifiers

PMID24217154
PMCPMC3929965
OpenAlexW2018765113

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.