ArticleThe Journal of clinical investigation2013
Allogeneic T cell responses are regulated by a specific miRNA-mRNA network.
Article in The Journal of clinical investigation, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Identification of novel microRNA signatures linked to acquired aplastic anemia.Haematologica · 2015Trial
- Profiling T cell activation using single-molecule fluorescence in situ hybridization and flow cytometry.Journal of immunology (Baltimore, Md. : 1950) · 2015Trial
- Rearrangement of T Cell genome architecture regulates GVHD.iScience · 2022Article
- MicroRNA expression profiling after recurrent febrile seizures in rat and emerging role of miR-148a-3p/SYNJ1 axis.Scientific reports · 2021Article
- miR-142 controls metabolic reprogramming that regulates dendritic cell activation.The Journal of clinical investigation · 2019Article
- Graft-Versus-Host Disease-Free Antitumoral Signature After Allogeneic Donor Lymphocyte Injection Identified by Proteomics and Systems Biology.JCO precision oncology · 2019Article
- MDHGI: Matrix Decomposition and Heterogeneous Graph Inference for miRNA-disease association prediction.PLoS computational biology · 2018Article
- Inferring potential small molecule-miRNA association based on triple layer heterogeneous network.Journal of cheminformatics · 2018Article
- TLHNMDA: Triple Layer Heterogeneous Network Based Inference for MiRNA-Disease Association Prediction.Frontiers in genetics · 2018Article
- Non-Coding RNA Mediated Regulation of Allogeneic T Cell Responses After Hematopoietic Transplantation.Frontiers in immunology · 2018Review
- Role of Circulating MicroRNAs in the Immunopathogenesis of Rejection After Pediatric Lung Transplantation.Transplantation · 2017Article
- Serum miR-29a Is Upregulated in Acute Graft-versus-Host Disease and Activates Dendritic Cells through TLR Binding.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Serum and Extracellular Vesicle MicroRNAs miR-423, miR-199, and miR-93* As Biomarkers for Acute Graft-versus-Host Disease.Frontiers in immunology · 2017Article
- Association of Serum MiR-142-3p and MiR-101-3p Levels with Acute Cellular Rejection after Heart Transplantation.PloS one · 2017Article
- Transcriptome analysis of GVHD reveals aurora kinase A as a targetable pathway for disease prevention.Science translational medicine · 2015Article
- MicroRNA-181a, a potential diagnosis marker, alleviates acute graft versus host disease by regulating IFN-γ production.American journal of hematology · 2015Article
- MicroRNA-17-92 controls T-cell responses in graft-versus-host disease and leukemia relapse in mice.Blood · 2015Article
- Mature T cell responses are controlled by microRNA-142.The Journal of clinical investigation · 2015Article
- Identification of ncRNAs as potential therapeutic targets in multiple sclerosis through differential ncRNA - mRNA network analysis.BMC genomics · 2015Article
- Review
Corrections and comments
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
Donor T cells that respond to host alloantigens following allogeneic bone marrow transplantation (BMT) induce graft-versus-host (GVH) responses, but their molecular landscape is not well understood. MicroRNAs (miRNAs) regulate gene (mRNA) expression and fine-tune the molecular responses of T cells. We stimulated naive T cells with either allogeneic or nonspecific stimuli and used argonaute cross-linked immunoprecipitation (CLIP) with subsequent ChIP microarray analyses to profile miR responses and their direct mRNA targets. We identified a unique expression pattern of miRs and mRNAs following the allostimulation of T cells and a high correlation between the expression of the identified miRs and a reduction of their mRNA targets. miRs and mRNAs that were predicted to be differentially regulated in allogeneic T cells compared with nonspecifically stimulated T cells were validated in vitro. These analyses identified wings apart-like homolog (Wapal) and synaptojanin 1 (Synj1) as potential regulators of allogeneic T cell responses. The expression of these molecular targets in vivo was confirmed in MHC-mismatched experimental BMT. Targeted silencing of either Wapal or Synj1 prevented the development of GVH response, confirming a role for these regulators in allogeneic T cell responses. Thus, this genome-wide analysis of miRNA-mRNA interactions identifies previously unrecognized molecular regulators of T cell responses.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.