ArticleJournal of neural engineering2013
Facilitation of memory encoding in primate hippocampus by a neuroprosthesis that promotes task-specific neural firing.
Article in Journal of neural engineering, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed, 115 citations in OpenAlex.
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- Patterned Hippocampal Stimulation Facilitates Memory in Patients With a History of Head Impact and/or Brain Injury.Frontiers in human neuroscience · 2022Article
- Brain augmentation and neuroscience technologies: current applications, challenges, ethics and future prospects.Frontiers in systems neuroscience · 2022Review
- Multimodal deep learning models for early detection of Alzheimer's disease stage.Scientific reports · 2021Article
- Delaying memory decline: different options and emerging solutions.Translational psychiatry · 2020Review
- Memory Prosthesis: Is It Time for a Deep Neuromimetic Computing Approach?Frontiers in neuroscience · 2019Article
- Neurotechnologies for Human Cognitive Augmentation: Current State of the Art and Future Prospects.Frontiers in human neuroscience · 2019Review
- A Multi-Channel Asynchronous Neurostimulator With Artifact Suppression for Neural Code-Based Stimulations.Frontiers in neuroscience · 2019Article
- Developing a hippocampal neural prosthetic to facilitate human memory encoding and recall.Journal of neural engineering · 2018Article
- Neurostimulation for Memory Enhancement in Epilepsy.Current neurology and neuroscience reports · 2018Review
- Sparse Large-Scale Nonlinear Dynamical Modeling of Human Hippocampus for Memory Prostheses.IEEE transactions on neural systems and rehabilitation engineering : a publication of the IEEE Engineering in Medicine and Biology Society · 2018Article
- Is Anyone Home? A Way to Find Out If AI Has Become Self-Aware.Frontiers in robotics and AI · 2018Article
- Evolving Applications, Technological Challenges and Future Opportunities in Neuromodulation: Proceedings of the Fifth Annual Deep Brain Stimulation Think Tank.Frontiers in neuroscience · 2017Article
- A cognitive prosthesis for memory facilitation by closed-loop functional ensemble stimulation of hippocampal neurons in primate brain.Experimental neurology · 2017Article
- Brain Implants to Erase Memories.Frontiers in neuroscience · 2017Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveMemory accuracy is a major problem in human disease and is the primary factor that defines Alzheimer's, ageing and dementia resulting from impaired hippocampal function in the medial temporal lobe. Development of a hippocampal memory neuroprosthesis that facilitates normal memory encoding in nonhuman primates (NHPs) could provide the basis for improving memory in human disease states. APPROACH: NHPs trained to perform a short-term delayed match-to-sample (DMS) memory task were examined with multi-neuron recordings from synaptically connected hippocampal cell fields, CA1 and CA3. Recordings were analyzed utilizing a previously developed nonlinear multi-input multi-output (MIMO) neuroprosthetic model, capable of extracting CA3-to-CA1 spatiotemporal firing patterns during DMS performance. MAIN
resultsThe MIMO model verified that specific CA3-to-CA1 firing patterns were critical for the successful encoding of sample phase information on more difficult DMS trials. This was validated by the delivery of successful MIMO-derived encoding patterns via electrical stimulation to the same CA1 recording locations during the sample phase which facilitated task performance in the subsequent, delayed match phase, on difficult trials that required more precise encoding of sample information. SIGNIFICANCE: These findings provide the first successful application of a neuroprosthesis designed to enhance and/or repair memory encoding in primate brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.