Evidence map›Paper›PMID 24216032›Full record

ArticleInternational journal of STD & AIDS2014

Rapid loss of vaccine-acquired hepatitis B surface antibody after three doses of hepatitis B vaccination in HIV-infected persons.

Masako Mizusawa, David C Perlman, David Lucido, Nadim Salomon

Abstract read
In one paragraph

Article in International journal of STD & AIDS, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 13 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Masako MizusawaBeth Israel Medical Center, New York, USA.
David C Perlman
David Lucido
Nadim Salomon
Mount Sinai Beth Israel · US

Funding

Transdisciplinary Theoretical Svnthesis and Development CoreP30DA011041 · NIDA · NEW YORK UNIVERSITY · PI Holly Hagan · 1998 to 2026
$38.9M
Hepatitis Care Coordination in Methadone TreatmentR01DA020841 · NIDA · BETH ISRAEL MEDICAL CTR (NEW YORK) · PI PERLMAN, DAVID C · 2006 to 2010
$1.7M
NIDA NIH HHS P30 DA011041NIDA NIH HHS R01 DA020841
6 · The paper itself

Abstract

HIV-infected individuals have poor responses to hepatitis B vaccine and may have decreased durability of post-vaccination immunity. Retrospective chart review was conducted for HIV-1 positive individuals aged ≥18 years who received hepatitis B vaccine at an urban HIV clinic. A total of 309 patients completed three doses and 178 had post-vaccine serology testing after the third dose. In multivariate analysis, time between the third dose and the first post-vaccine serology testing at 180-359 days (OR = 0.077, p = 0.049) and at ≥360 days (OR = 0.065, p = 0.019) were associated with poor vaccine responses. A significant decrease in seropositivity appeared as early as 180 days after the third vaccine dose, suggesting a rapid loss of vaccine-acquired hepatitis B surface antibody in HIV-infected persons. Our findings suggest that hepatitis B surface antibody should be tested at 6 to 12 months after completing primary vaccine series in order to detect early secondary vaccine failure.

Indexed as

Antiviral AgentsCD4 Lymphocyte CountDose-Response Relationship, ImmunologicFemaleHepatitis BHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B VaccinesHepatitis B virusHIV-1HIV InfectionsHumansImmunization ScheduleMaleRetrospective StudiesTreatment OutcomeAntiviral AgentsHepatitis B AntibodiesHepatitis B Core AntigensHepatitis B VaccinesAIDShepatitis BHIVhuman immunodeficiency viruspost-vaccination immunityvaccinationvaccine responseviral disease

Identifiers

PMID24216032
PMCPMC4442633
OpenAlexW2312821988

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.