ArticleNeuroscience2014
Ingestion of bacterial lipopolysaccharide inhibits peripheral taste responses to sucrose in mice.
Article in Neuroscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 31 citations in OpenAlex.
- Trial
- Suprathreshold non-volatile flavour perception is associated with multiple species rather than any single species via bacterial metabolism.Journal of oral microbiology · 2026Article
- Inflammatory models of depression in rodents and humans.Frontiers in psychiatry · 2026Review
- L-proline supplementation affects non-volatile flavour perception through oral microbiome metabolic pathways.NPJ science of food · 2025Article
- Exendin-4 blockade of T1R2/T1R3 activation improves Pseudomonas aeruginosa-related pneumonia in an animal model of chemically induced diabetes.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2024Article
- Microbiota-gut-brain axis in binge-eating disorder: Towards microbiome-based therapies.Neuroscience applied · 2024Review
- Altered peripheral taste function in a mouse model of inflammatory bowel disease.Scientific reports · 2023Article
- Interleukin (IL)-1 Receptor Signaling Is Required for Complete Taste Bud Regeneration and the Recovery of Neural Taste Responses following Axotomy.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Microbiota and body weight control: Weight watchers within?Molecular metabolism · 2022Review
- Regulation effect of lipopolysaccharide on the alternative splicing and function of sweet taste receptor T1R2.Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2021Article
- Do Gut Microbes Taste?Nutrients · 2021Review
- Review
- Ecological Sensing Through Taste and Chemosensation Mediates Inflammation: A Biological Anthropological Approach.Advances in nutrition (Bethesda, Md.) · 2020Review
- Behavioral and neurophysiological taste responses to sweet and salt are diminished in a model of subclinical intestinal inflammation.Scientific reports · 2020Article
- Lipopolysaccharide-Induced Inflammatory Cytokine Expression in Taste Organoids.Chemical senses · 2020Article
- Chronic exposure to liquid sucrose and dry sucrose diet have differential effects on peripheral taste responses in female rats.Appetite · 2020Article
- The gut microbiota to the brain axis in the metabolic control.Reviews in endocrine & metabolic disorders · 2019Review
- The Toll-Like Receptor 3 Agonist Poly(I:C) Induces Rapid and Lasting Changes in Gene Expression Related to Glutamatergic Function and Increases Ethanol Self-Administration in Rats.Alcoholism, clinical and experimental research · 2019Article
- The effect of imiquimod on taste bud calcium transients and transmitter secretion.British journal of pharmacology · 2016Article
- What Does Diabetes "Taste" Like?Current diabetes reports · 2016Review
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
Abstract
A fundamental role of the taste system is to discriminate between nutritive and toxic foods. However, it is unknown whether bacterial pathogens that might contaminate food and water modulate the transmission of taste input to the brain. We hypothesized that exogenous, bacterially-derived lipopolysaccharide (LPS), modulates neural responses to taste stimuli. Neurophysiological responses from the chorda tympani nerve, which innervates taste cells on the anterior tongue, were unchanged by acute exposure to LPS. Instead, neural responses to sucrose were selectively inhibited in mice that drank LPS during a single overnight period. Decreased sucrose sensitivity appeared 7days after LPS ingestion, in parallel with decreased lingual expression of Tas1r2 and Tas1r3 transcripts, which are translated to T1R2+T1R3 subunits forming the sweet taste receptor. Tas1r2 and Tas1r3 mRNA expression levels and neural responses to sucrose were restored by 14 days after LPS consumption. Ingestion of LPS, rather than contact with taste receptor cells, appears to be necessary to suppress sucrose responses. Furthermore, mice lacking the Toll-like receptor (TLR) 4 for LPS were resistant to neurophysiological changes following LPS consumption. These findings demonstrate that ingestion of LPS during a single period specifically and transiently inhibits neural responses to sucrose. We suggest that LPS drinking initiates TLR4-dependent hormonal signals that downregulate sweet taste receptor genes in taste buds. Delayed inhibition of sweet taste signaling may influence food selection and the complex interplay between gastrointestinal bacteria and obesity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.