ArticleJournal of affective disorders2014
Perinatal factors and the risk of bipolar disorder in Finland.
Article in Journal of affective disorders, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 3 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 3 syntheses or guidelines pooled it, 66 citations in OpenAlex.
- Cognitive and academic outcomes of large-for-gestational-age babies born at early term: A systematic review and meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2025Pooled it
- Environmental Risk Factors in Bipolar Disorder and Psychotic Depression: A Systematic Review and Meta-Analysis of Prospective Studies.Schizophrenia bulletin · 2021Pooled it
- Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis.JAMA network open · 2019Pooled it
- Mode of delivery among preterm twins and offspring health, a retrospective cohort study.European journal of pediatrics · 2025Article
- Maternal early pregnancy body mass index and bipolar disorder in the offspring.Bipolar disorders · 2024Article
- Impaired neural stress resistance and loss of REST in bipolar disorder.Molecular psychiatry · 2024Article
- Cesarean section induced dysbiosis promotes type 2 immunity but not oxazolone-induced dermatitis in mice.Gut microbes · 2023Article
- Associations of pregnancy complications and neonatal characteristics with bipolar disorder in the offspring: Nationwide cohort and sibling-controlled studies.Bipolar disorders · 2023Article
- Role of the gut microbiome in three major psychiatric disorders.Psychological medicine · 2022Review
- Birth signalling hormones and the developmental consequences of caesarean delivery.Journal of neuroendocrinology · 2021Review
- Birth by cesarean section and mood disorders among adolescents of a birth cohort study in northern Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021Article
- Maternal Immune Activation and the Development of Dopaminergic Neurotransmission of the Offspring: Relevance for Schizophrenia and Other Psychoses.Frontiers in psychiatry · 2020Review
- The role of pre-, peri-, and postnatal risk factors in bipolar disorder and adult ADHD.Journal of neural transmission (Vienna, Austria : 1996) · 2019Article
- Dynamic expression of genes associated with schizophrenia and bipolar disorder across development.Translational psychiatry · 2019Article
- Neurodevelopmental subtypes of bipolar disorder are related to cortical folding patterns: An international multicenter study.Bipolar disorders · 2018Article
- Perinatal risk factors in Tourette's and chronic tic disorders: a total population sibling comparison study.Molecular psychiatry · 2018Article
- Intervention strategies for cesarean section-induced alterations in the microbiota-gut-brain axis.Nutrition reviews · 2017Review
- Environmental factors, life events, and trauma in the course of bipolar disorder.Psychiatry and clinical neurosciences · 2017Review
- Birth by Caesarean Section and the Risk of Adult Psychosis: A Population-Based Cohort Study.Schizophrenia bulletin · 2016Article
- The Kraepelinian Dichotomy From the Perspective of Prenatal Infectious and Immunologic Insults.Schizophrenia bulletin · 2015Review
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 3 countries.
Funding
Abstract
backgroundComplications during the perinatal period have been associated with neurodevelopmental disorders like schizophrenia and autism. However, similar studies on bipolar disorder (BPD) have been limited and the findings are inconsistent. The aim of this study was to examine the association between perinatal risk factors and BPD.
methodsThis nested case-control study, based on the Finnish Prenatal Study of Bipolar Disorders (FIPS-B), identified 724 cases and 1419 matched controls from population based registers. Conditional logistic regression was used to examine the associations between perinatal factors and BPD adjusting for potential confounding due to maternal age, psychiatric history and educational level, place of birth, number of previous births and maternal smoking during pregnancy.
resultsChildren delivered by planned cesarean section had a 2.5-fold increased risk of BPD (95% CI: 1.32-4.78, P<0.01). No association was seen between other examined perinatal risk factors and BPD. LIMITATIONS: The limitations of this study include: the restriction in the sample to treated cases of BPD in the population, and usage of hospital based clinical diagnosis for case ascertainment. In addition, in spite of the large sample size, there was low power to detect associations for certain exposures including the lowest birth weight category and pre-term birth.
conclusionsBirth by planned cesarean section was associated with risk of BPD, but most other perinatal risk factors examined in this study were not associated with BPD. Larger studies with greater statistical power to detect less common exposures and studies utilizing prospective biomarker-based exposures are necessary in the future.
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Registered trials
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