Evidence map›Paper›PMID 24215863›Full record

ReviewProtein expression and purification2014

Developments in purification methods for obtaining and evaluation of collagen derived endogenous angioinhibitors.

Venugopal Gunda, Raj K Verma, Smita C Pawar, Yakkanti A Sudhakar

Abstract readReview
In one paragraph

Review in Protein expression and purification, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 4 institutions in 2 countries.

Venugopal GundaThe Eppley Institute for Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Raj K VermaIrma Lerma Rangel College of Pharmacy, Texas A&M Health Science Center, 78363, USA.
Smita C PawarDepartment of Genetics, Osmania University, Hyderabad, AP 500007, India.
Yakkanti A SudhakarCell Signaling Laboratory, Center for Cancer and Metabolism, Bioscience Division, SRI International, Menlo Park, CA 94025, USA. Electronic address: sudhakar.yakkanti@sri.com.
Osmania University · INSRI International · USTexas A&M Health Science Center · USUniversity of Nebraska Medical Center · US

Funding

SIGNALING MECHANISMS IN REGULATION OF TUMOR ANGIOGENESISR01CA143128 · NCI · FATHER FLANAGAN'S BOYS' HOME · PI COSGROVE, DOMINIC E. · 2010 to 2012
$802k
NCI NIH HHS R01 CA143128NCI NIH HHS R01CA143128
6 · The paper itself

Abstract

Collagen constitutes one of the vital components of the basement membrane scaffolds. Non-collagenous domains (NC1) derived from collagens exhibit potent anti-angiogenic properties, thus attaining significance in regulation of angiogenesis promoted diseases. Individual NC1 domains essential for anti-angiogenic evaluations are generally obtained through purification of individual non-collagenous domains, which have undergone steady developments for enhancing the yields, purpose of biological evaluations and solubility based on the nature of different NC1 domains. This review focuses on the method developments in obtaining biologically active NC1 domains and for specific evaluations in different scenarios.

Indexed as

Protein Structure, TertiaryAngiogenesis InhibitorsBasement MembraneCollagen Type IVExtracellular MatrixGene Expression RegulationHumansAngiogenesis InhibitorsCollagen Type IVAnti-angiogenesisDifferent expression systemsDifferent purification methodsExtra cellular matrix (ECM)Non-collagenous domains (NC1)Type IV collagen

Identifiers

PMID24215863
PMCPMC3914668
OpenAlexW2038925074

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.