Evidence map›Paper›PMID 24215858›Full record

Trial reportAmerican journal of obstetrics and gynecology2014

Menopausal quality of life: RCT of yoga, exercise, and omega-3 supplements.

Susan D Reed, Katherine A Guthrie, Katherine M Newton, Garnet L Anderson, Cathryn Booth-LaForce, Bette Caan, Janet S Carpenter, Lee S Cohen, Andrea L Dunn, Kristine E Ensrud and 10 more

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in American journal of obstetrics and gynecology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05764031 (Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression), which is not on this map. Cited by 35 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05764031 nacompletednot on this mapstarted 2020, after this paper: background citation

Comparative Effects of Clinical Pilates Training and Aerobic Exercise on Menopausal Symptoms, Quality of Life, Sleep and Depression

TypeinterventionalSponsorHasan Kalyoncu UniversityRan2020 to 2022Enrolled30ConditionsMenopauseArmsClinical pilates exercise, Aerobic exercise
3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 7 syntheses or guidelines pooled it.

  1. Pooled it
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  6. Survivorship, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology.Journal of the National Comprehensive Cancer Network : JNCCN · 2017
    Guideline
  7. Pooled it
  8. Trial
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  12. Is heart rate variability associated with frequency and intensity of vasomotor symptoms among healthy perimenopausal and postmenopausal women?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2016
    Trial
  13. Trial
  14. Review
  15. Review
  16. Review
  17. Article
  18. Review
  19. Review
  20. The Effect of Body Practices and Physical Exercise on Sexual Function of Menopausal Women. A Systematic Review with Meta-Analysis.International journal of sexual health : official journal of the World Association for Sexual Health · 2023
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors.

Susan D ReedDepartments of Obstetrics and Gynecology and Epidemiology, University of Washington School of Medicine, Seattle, WA. Electronic address: reeds@u.washington.edu.
Katherine A GuthrieData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA.
Katherine M NewtonGroup Health Research Institute, Seattle, WA.
Garnet L AndersonData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA.
Cathryn Booth-LaForceSchool of Nursing, University of Washington, Seattle, WA.
Bette CaanDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Janet S CarpenterSchool of Nursing, Indiana University, Indianapolis, IN.
Lee S CohenDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA.
Andrea L DunnKlein Buendel, Inc, Golden, CO.
Kristine E EnsrudDepartment of Medicine, VA Medical Center, and Department of Medicine and Division of Epidemiology and Community Health, University of Minnesota, Minneapolis, MN.
Ellen W FreemanDepartments of Obstetrics and Gynecology and Psychiatry, University of Pennsylvania School of Medicine, Philadelphia, PA.
Julie R HuntData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA.
Hadine JoffeDepartment of Psychiatry, Massachusetts General Hospital, Boston, MA; Brigham and Women's Hospital and Dana Farber Cancer Institute, Boston, MA.
Joseph C LarsonData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA.
Lee A LearmanDepartment of Obstetrics and Gynecology, Indiana University School of Medicine, Indianapolis, IN.
Robin RothenbergEssential Yoga Therapy, Fall City, WA.
Rebecca A SeguinData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA; Division of Nutritional Sciences, Cornell University, Ithaca, NY.
Karen J ShermanGroup Health Research Institute, Seattle, WA.
Barbara S SternfeldDivision of Research, Kaiser Permanente Northern California, Oakland, CA.
Andrea Z LaCroixData Coordinating Center, Fred Hutchinson Cancer Research Center, Seattle, WA.

Funding

Menopausal Symptoms Initiative-Finding Lasting Answers for Sweats and Hot FlashesU01AG032699 · NIA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GUTHRIE, KATHERINE ADAMS, LACROIX, ANDREA Z. · 2008 to 2012
$13.5M
MsFLASH: Living a Healthy MenopauseR01AG048209 · NIA · FRED HUTCHINSON CANCER RESEARCH CENTER · PI GUTHRIE, KATHERINE ADAMS, LACROIX, ANDREA Z. · 2015 to 2019
$7.2M
MSI-FLASH: Relative Efficacy of Hormonal and Non-Hormonal Interventions for VMSU01AG032700 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI COHEN, LEE S, JOFFE, HADINE · 2008 to 2012
$1.7M
MSI FLASH: An RCT of Yoga and Ultra Low-Dose Estrogen Gel for Vasomotor SymptomsU01AG032682 · NIA · KAISER FOUNDATION HEALTH PLAN OF WASHINGTON · PI NEWTON, KATHERINE M. · 2008 to 2012
$1.7M
Efficacy of an SSRI for Menopausal Symptoms in Perimenopausal WomenU01AG032656 · NIA · UNIVERSITY OF PENNSYLVANIA · PI FREEMAN, ELLEN W · 2008 to 2012
$1.5M
MSI-FLASH: Paced Respiration for Breast Cancer SurvivorsU01AG032659 · NIA · INDIANA UNIVERSITY INDIANAPOLIS · PI CARPENTER, JANET S · 2008 to 2012
$1.5M
MSI-FLASH: An Exercise Intervention for Women with Menopausal SymptomsU01AG032669 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CAAN, BETTE J · 2008 to 2012
$1.5M
NCRR NIH HHS UL1RR02571NIA NIH HHS R01 AG048209NIA NIH HHS U01 AG032656NIA NIH HHS U01 AG032659NIA NIH HHS U01AG032659NIA NIH HHS U01 AG032669NIA NIH HHS U01AG032669NIA NIH HHS U01 AG032682NIA NIH HHS U01AG032682NIA NIH HHS U01 AG032699NIA NIH HHS U01AG032699NIA NIH HHS U01 AG032700NIA NIH HHS U01AG032700
6 · The paper itself

Abstract

objectiveThe purpose of this study was to determine the efficacy of 3 nonhormonal therapies for the improvement of menopause-related quality of life in women with vasomotor symptoms. STUDY

designWe conducted a 12-week 3 × 2 randomized, controlled, factorial design trial. Peri- and postmenopausal women, 40-62 years old, were assigned randomly to yoga (n = 107), exercise (n = 106), or usual activity (n = 142) and also assigned randomly to a double-blind comparison of omega-3 (n = 177) or placebo (n = 178) capsules. We performed the following interventions: (1) weekly 90-minute yoga classes with daily at-home practice, (2) individualized facility-based aerobic exercise training 3 times/week, and (3) 0.615 g omega-3 supplement, 3 times/day. The outcomes were assessed with the following scores: Menopausal Quality of Life Questionnaire (MENQOL) total and domain (vasomotor symptoms, psychosocial, physical and sexual).

resultsAmong 355 randomly assigned women who average age was 54.7 years, 338 women (95%) completed 12-week assessments. Mean baseline vasomotor symptoms frequency was 7.6/day, and the mean baseline total MENQOL score was 3.8 (range, 1-8 from better to worse) with no between-group differences. For yoga compared to usual activity, baseline to 12-week improvements were seen for MENQOL total -0.3 (95% confidence interval, -0.6 to 0; P = .02), vasomotor symptom domain (P = .02), and sexuality domain (P = .03) scores. For women who underwent exercise and omega-3 therapy compared with control subjects, improvements in baseline to 12-week total MENQOL scores were not observed. Exercise showed benefit in the MENQOL physical domain score at 12 weeks (P = .02).

conclusionAll women become menopausal, and many of them seek medical advice on ways to improve quality of life; little evidence-based information exists. We found that, among healthy sedentary menopausal women, yoga appears to improve menopausal quality of life; the clinical significance of our finding is uncertain because of the modest effect.

Indexed as

Dietary SupplementsAdultDouble-Blind MethodExerciseFatty Acids, Omega-3FemaleHot FlashesHumansMenopauseMiddle AgedQuality of LifeTreatment OutcomeYogaFatty Acids, Omega-3exercisemenopauseomega-3quality of liferandomized controlled trialyoga

Identifiers

PMID24215858
PMCPMC3976276

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.