Evidence map›Paper›PMID 24215592›Full record

Trial reportNutrition journal2013

Alternate day fasting for weight loss in normal weight and overweight subjects: a randomized controlled trial.

Krista A Varady, Surabhi Bhutani, Monica C Klempel, Cynthia M Kroeger, John F Trepanowski, Jacob M Haus, Kristin K Hoddy, Yolian Calvo

3 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrition journal, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 184 papers, 23 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
184citing papers in PubMed, 23 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03372109 nacompletednot on this mapstarted 2017, after this paper: background citation

A Randomized Controlled Trial to Evaluate the Effects of Repeated Periods of Modified Fasting to Support Healthy Natural Weight Management and Prevention of Weight Gain in Overweight But Generally Healthy Adults Over the Winter Holiday Period

TypeinterventionalSponsorSupplement Formulators, Inc.Ran2017 to 2018Enrolled23ConditionsBody Weight ChangesArmsMeal replacement shake, Multivitamin and mineral capsules, Fish oil with sesame lignans and olive extract softgel, Prebiotic Chewable tablet, Clove Extract and Maqui Berry extract capsule
NCT04133701 nacompletednot on this mapstarted 2022, after this paper: background citation

The Impact of Meal Timing on Neurovascular Control in Adults

TypeinterventionalSponsorUniversity of Wisconsin, MadisonRan2022 to 2022Enrolled34ConditionsBlood Pressure, Neurovascular ControlArmsTime-Restricted Feeding
NCT05219240 unknown statusnot on this mapstarted 2020, after this paper: background citation

Evaluation of Body Composition Improvement With Visceral Adiposity-Focused Anti-Obesity Telehealth Program

TypeobservationalSponsor20LighterRan2020 to 2024Enrolled2,000ConditionsObesity, Cardiovascular Diseases, Metabolic Syndrome, Metabolic DiseaseArms20Lighter Program
3 · Its place in the literature

Who cites it

184 citing papers in PubMed, 23 syntheses or guidelines pooled it, 390 citations in OpenAlex.

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  17. Intermittent fasting for the prevention of cardiovascular disease.The Cochrane database of systematic reviews · 2021
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  20. The Influence of Fasting and Energy Restricting Diets on Blood Pressure in Humans: A Systematic Review and Meta-Analysis.High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2020
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124 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Krista A VaradyDepartment of Kinesiology and Nutrition, University of Illinois at Chicago, 1919 West Taylor Street, Room 506 F, Chicago, IL 60612, USA. varady@uic.edu.
Surabhi Bhutani
Monica C Klempel
Cynthia M Kroeger
John F Trepanowski
Jacob M Haus
Kristin K Hoddy
Yolian Calvo
University of Illinois Chicago · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAlternate day fasting (ADF; ad libitum "feed day", alternated with 25% energy intake "fast day"), is effective for weight loss and cardio-protection in obese individuals. Whether these effects occur in normal weight and overweight individuals remains unknown. This study examined the effect of ADF on body weight and coronary heart disease risk in non-obese subjects.

methodsThirty-two subjects (BMI 20-29.9 kg/m2) were randomized to either an ADF group or a control group for 12 weeks.

resultsBody weight decreased (P < 0.001) by 5.2 ± 0.9 kg (6.5 ± 1.0%) in the ADF group, relative to the control group, by week 12. Fat mass was reduced (P < 0.001) by 3.6 ± 0.7 kg, and fat free mass did not change, versus controls. Triacylglycerol concentrations decreased (20 ± 8%, P < 0.05) and LDL particle size increased (4 ± 1 Å, P < 0.01) in the ADF group relative to controls. CRP decreased (13 ± 17%, P < 0.05) in the ADF group relative to controls at week 12. Plasma adiponectin increased (6 ± 10%, P < 0.01) while leptin decreased (40 ± 7%, P < 0.05) in the ADF group versus controls by the end of the study. LDL cholesterol, HDL cholesterol, homocysteine and resistin concentrations remained unchanged after 12 weeks of treatment.

conclusionThese findings suggest that ADF is effective for weight loss and cardio-protection in normal weight and overweight adults, though further research implementing larger sample sizes is required before solid conclusion can be reached.

Indexed as

Diet, ReducingFastingWeight LossAdiponectinAdultAgedBody CompositionBody Mass IndexCholesterol, HDLCholesterol, LDLCoronary DiseaseEnergy IntakeFemaleHumansLeptinMaleAdiponectinCholesterol, HDLCholesterol, LDLLeptinTriglycerides

Identifiers

PMID24215592
PMCPMC3833266
OpenAlexW2151715700

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.