ArticlePhotochemistry and photobiology
Hydrogel-forming and dissolving microneedles for enhanced delivery of photosensitizers and precursors.
Article in Photochemistry and photobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 107 citations in OpenAlex.
- Polymeric microneedle advancements in macromolecule drug delivery: current trends, challenges, and future perspectives.Naunyn-Schmiedeberg's archives of pharmacology · 2025Review
- Microneedle-Mediated Transdermal Drug Delivery for the Treatment of Multiple Skin Diseases.Pharmaceutics · 2025Review
- Multifunctional Hydrogel Microneedles (HMNs) in Drug Delivery and Diagnostics.Gels (Basel, Switzerland) · 2025Review
- Synergistic Strategies of Biomolecular Transport Technologies in Transdermal Healthcare Systems.Advanced healthcare materials · 2024Review
- Hydrogel-Based Microneedle as a Drug Delivery System.Pharmaceutics · 2023Review
- Advances and Prospects for Hydrogel-Forming Microneedles in Transdermal Drug Delivery.Biomedicines · 2023Review
- Hydrogel-Forming Microneedles with Applications in Oral Diseases Management.Materials (Basel, Switzerland) · 2023Review
- Microneedles forMaterials today. Bio · 2023Review
- A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications.Polymers · 2021Review
- Micro- and Nano-Based Transdermal Delivery Systems of Photosensitizing Drugs for the Treatment of Cutaneous Malignancies.Pharmaceuticals (Basel, Switzerland) · 2021Review
- Smart Polymeric Delivery System for Antitumor and Antimicrobial Photodynamic Therapy.Frontiers in bioengineering and biotechnology · 2021Review
- An update on coating/manufacturing techniques of microneedles.Drug delivery and translational research · 2018Review
- Hydrogel-forming microneedles enhance transdermal delivery of metformin hydrochloride.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Synthesis and Characterization of Lignin Hydrogels for Potential Applications as Drug Eluting Antimicrobial Coatings for Medical Materials.ACS sustainable chemistry & engineering · 2018Article
- Transdermal delivery of vitamin K using dissolving microneedles for the prevention of vitamin K deficiency bleeding.International journal of pharmaceutics · 2018Article
- Microneedles: A New Frontier in Nanomedicine Delivery.Pharmaceutical research · 2016Review
- A novel scalable manufacturing process for the production of hydrogel-forming microneedle arrays.International journal of pharmaceutics · 2015Article
- Methylene Blue-Loaded Dissolving Microneedles: Potential Use in Photodynamic Antimicrobial Chemotherapy of Infected Wounds.Pharmaceutics · 2015Article
- Microneedle characterisation: the need for universal acceptance criteria and GMP specifications when moving towards commercialisation.Drug delivery and translational research · 2015Review
- Microwave-Assisted Preparation of Hydrogel-Forming Microneedle Arrays for Transdermal Drug Delivery Applications.Macromolecular materials and engineering · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 3 countries.
Funding
Abstract
We present "one-step application" dissolving and hydrogel-forming microneedle arrays (MN) for enhanced delivery of photosensitizers/precursors. MN (280 μm) prepared from 20% w/w poly(methylvinylether/maelic acid) and cross-linked with glycerol by esterification to form hydrogels upon skin insertion, or allowed to dissolve rapidly in skin, were combined with patches containing 19 mg cm(-2) of 5-aminolevulinic acid (ALA) or meso-tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP) for drug delivery. Both MN types were mechanically robust, with compression forces of 20.0 N only causing height reductions of 14%. Application forces as low as 8.0 N per array allowed >95% of the MN in each array type to penetrate excised porcine skin, with the MN penetrating to approximately 220 μm. MN significantly enhanced transdermal delivery of ALA and TMP in vitro, with the hydrogel-forming system comparable with the dissolving system for ALA delivery (approximately 3000 nmol cm(-2) over 6 h), but superior for delivery of the much larger TMP molecule (approximately 14 nmol cm(-2) over 24 h, compared to 0.15 nmol cm(-2)). As this technology clearly has potential in enhanced photodynamic therapy of neoplastic skin lesions, we are currently planning animal studies, to be followed by preliminary human evaluations. GMP manufacturing scale-up is ongoing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.