Evidence map›Paper›PMID 24215442›Full record

ReviewAnnual review of physiology2014

Nanoparticles, lung injury, and the role of oxidant stress.

Amy K Madl, Laurel E Plummer, Christopher Carosino, Kent E Pinkerton

Abstract readReview
In one paragraph

Review in Annual review of physiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed.

  1. Article
  2. Ambient PMBMC public health · 2026
    Article
  3. Conversion of COJournal of environmental chemical engineering · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Lung-on-a-Chip Models of the Lung Parenchyma.Advances in experimental medicine and biology · 2023
    Article
  11. Article
  12. Review
  13. Green Synthesis of Silver Nanoparticles Using AqueousNanomaterials (Basel, Switzerland) · 2022
    Article
  14. Article
  15. Article
  16. External Environmental Pollution as a Risk Factor for Asthma.Clinical reviews in allergy & immunology · 2022
    Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Amy K MadlCenter for Health and the Environment, University of California, Davis, California 95616; email: akmadl@ucdavis.edu , kepinkerton@ucdavis.edu.
Laurel E Plummer
Christopher Carosino
Kent E Pinkerton

Funding

ZONA PELLUCIDA PEPTIDES AS IMMUNOCONTRACEPTIVE ANTIGENSP51RR000169 · NCRR · UNIVERSITY OF CALIFORNIA DAVIS · PI HYDE, DALLAS MELVIN · 1985 to 2011
$126.2M
Western Center for Agricultural Health and SafetyU54OH007550 · OH · UNIVERSITY OF CALIFORNIA AT DAVIS · PI FATHALLAH, FADI A · 2011 to 2025
$27.5M
ROLE OF EPITHELIAL CELLS IN OZONE-NITROGEN DIOXIDE INTERACTIONP01ES000628 · NIEHS · UNIVERSITY OF CALIFORNIA DAVIS · PI PLOPPER, CHARLES GEORGE · 1985 to 2010
$12.5M
The Western Center for Agricultural Health and Safety at UC DavisU50OH007550 · OH · UNIVERSITY OF CALIFORNIA DAVIS · PI SCHENKER, MARC B · 2001 to 2010
$5.4M
Engineered Nanomaterials: Linking Physical and Chemical Properties to BiologyU01ES020127 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED · 2010 to 2014
$2.5M
Novel approaches to evaluate carbon nanotube health impactsRC1ES018232 · NIEHS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI PINKERTON, KENT ED · 2009 to 2010
$1.0M
NCRR NIH HHS P51 RR000169NCRR NIH HHS RR00169NIEHS NIH HHS P01 ES000628NIEHS NIH HHS P01 ES00628NIEHS NIH HHS RC1 ES018232NIEHS NIH HHS U01 ES020127NIEHS NIH HHS U01 ES02027NIOSH CDC HHS OH07550NIOSH CDC HHS U54 OH007550
6 · The paper itself

Abstract

The emergence of engineered nanoscale materials has provided significant advancements in electronic, biomedical, and material science applications. Both engineered nanoparticles and nanoparticles derived from combustion or incidental processes exhibit a range of physical and chemical properties that induce inflammation and oxidative stress in biological systems. Oxidative stress reflects the imbalance between the generation of reactive oxygen species and the biochemical mechanisms to detoxify and repair the damage resulting from reactive intermediates. This review examines current research on incidental and engineered nanoparticles in terms of their health effects on lungs and the mechanisms by which oxidative stress via physicochemical characteristics influences toxicity or biocompatibility. Although oxidative stress has generally been thought of as an adverse biological outcome, this review also briefly discusses some of the potential emerging technologies to use nanoparticle-induced oxidative stress to treat disease in a site-specific fashion.

Indexed as

Acute Lung InjuryAnimalsDNA DamageHumansNanoparticlesNanostructuresOxidative Stress

Identifiers

PMID24215442
PMCPMC4408931

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.