ArticleSchizophrenia bulletin2014
Identifying cognitive remediation change through computational modelling--effects on reinforcement learning in schizophrenia.
Article in Schizophrenia bulletin, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Effects of Cognitive Remediation on Negative Symptoms in Schizophrenia-Spectrum Illness: A Meta-analytic Investigation of Efficacy.Schizophrenia bulletin · 2025Pooled it
- Psychosocial and behavioural interventions for the negative symptoms of schizophrenia: a systematic review of efficacy meta-analyses.The British journal of psychiatry : the journal of mental science · 2023Pooled it
- A network approach exploring the effects of cognitive remediation on cognition, symptoms, and functioning in early psychosis.Psychological medicine · 2025Trial
- An experimental and computational investigation of executive functions and inner speech in schizophrenia spectrum disorders.Scientific reports · 2025Article
- Article
- The Association Between Prenatal Maternal Stress and Adolescent Affective Outcomes is Mediated by Childhood Maltreatment and Adolescent Behavioral Inhibition System Sensitivity.Child psychiatry and human development · 2024Article
- Personalized Cognitive Health in Psychiatry: Current State and the Promise of Computational Methods.Schizophrenia bulletin · 2024Review
- Article
- Reward Learning as a Potential Mechanism for Improvement in Schizophrenia Spectrum Disorders Following Cognitive Remediation: Protocol for a Clinical, Nonrandomized, Pre-Post Pilot Study.JMIR research protocols · 2024Article
- Changes in Learning From Social Feedback After Web-Based Interpretation Bias Modification: Secondary Analysis of a Digital Mental Health Intervention Among Individuals With High Social Anxiety Symptoms.JMIR formative research · 2023Article
- Neural Circuitry of Salience and Reward Processing in Psychosis.Biological psychiatry global open science · 2023Review
- Computational Methods in Psychotherapy: A Scoping Review.International journal of environmental research and public health · 2022Article
- Cognitive Remediation in Psychiatric Disorders: State of the Evidence, Future Perspectives, and Some Bold Ideas.Brain sciences · 2022Review
- Toward a Computational Neuropsychology of Cognitive Flexibility.Brain sciences · 2020Review
- Progress in Schizophrenia Research and Treatment.Focus (American Psychiatric Publishing) · 2020Article
- Parallel model-based and model-free reinforcement learning for card sorting performance.Scientific reports · 2020Article
- Could the severity of symptoms of schizophrenia affect ability of self-appraisal of cognitive deficits in patients with schizophrenia? Lack of insight as a mediator between the two domains.European archives of psychiatry and clinical neuroscience · 2020Article
- A Computational Study of Executive Dysfunction in Amyotrophic Lateral Sclerosis.Journal of clinical medicine · 2020Article
- Exploring the relationship between the anticipation and experience of pleasure in people with schizophrenia: An experience sampling study.Schizophrenia research · 2018Observational
- Deficits in reinforcement learning but no link to apathy in patients with schizophrenia.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveConverging research suggests that individuals with schizophrenia show a marked impairment in reinforcement learning, particularly in tasks requiring flexibility and adaptation. The problem has been associated with dopamine reward systems. This study explores, for the first time, the characteristics of this impairment and how it is affected by a behavioral intervention-cognitive remediation.
methodUsing computational modelling, 3 reinforcement learning parameters based on the Wisconsin Card Sorting Test (WCST) trial-by-trial performance were estimated: R (reward sensitivity), P (punishment sensitivity), and D (choice consistency). In Study 1 the parameters were compared between a group of individuals with schizophrenia (n = 100) and a healthy control group (n = 50). In Study 2 the effect of cognitive remediation therapy (CRT) on these parameters was assessed in 2 groups of individuals with schizophrenia, one receiving CRT (n = 37) and the other receiving treatment as usual (TAU, n = 34).
resultsIn Study 1 individuals with schizophrenia showed impairment in the R and P parameters compared with healthy controls. Study 2 demonstrated that sensitivity to negative feedback (P) and reward (R) improved in the CRT group after therapy compared with the TAU group. R and P parameter change correlated with WCST outputs. Improvements in R and P after CRT were associated with working memory gains and reduction of negative symptoms, respectively.
conclusionSchizophrenia reinforcement learning difficulties negatively influence performance in shift learning tasks. CRT can improve sensitivity to reward and punishment. Identifying parameters that show change may be useful in experimental medicine studies to identify cognitive domains susceptible to improvement.
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