ReviewCurrent psychiatry reports2013
Pain and depression: an integrative review of neurobiological and psychological factors.
Review in Current psychiatry reports, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 123 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
123 citing papers in PubMed, 5 syntheses or guidelines pooled it.
- Chronic pain in mental disorders: An umbrella review of the prevalence, risk factors, and treatments across 957,168 people with mental disorders and 16,606,910 controls.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Antidepressants for pain management in adults with chronic pain: a network meta-analysis.Health technology assessment (Winchester, England) · 2024Pooled it
- How do psychologically based interventions for chronic musculoskeletal pain work? A systematic review and meta-analysis of specific moderators and mediators of treatment.Clinical psychology review · 2022Pooled it
- The role of affect in chronic pain: A systematic review of within-person symptom dynamics.Journal of psychosomatic research · 2021Pooled it
- Pooled it
- The relationships between depression, inflammation and self-reported disease activity in IBD and their impact on healthcare usage.BMC gastroenterology · 2025Trial
- Facial expressions of pain: the role of the serotonergic system.Psychopharmacology · 2023Trial
- Short-Term Findings From Testing EPIO, a Digital Self-Management Program for People Living With Chronic Pain: Randomized Controlled Trial.Journal of medical Internet research · 2023Trial
- Pain characteristics and incidence of functional disability among community-dwelling older adults.PloS one · 2019Trial
- Mediators of the Pain-Depression Relationship in Adults with Chronic Pain: A Systematic Review and Exploratory Meta-Analyses.Journal of clinical medicine · 2026Review
- Focusing on depressive symptoms in patients to mitigate the risk of pain: a nationwide, prospective cohort study.BMC public health · 2026Observational
- Diagnostic sequence of chronic pain and severe mental illness: Relationship with mental health and hospitalization outcomes.British journal of pain · 2026Article
- Impact of Psychiatric Comorbidity on Outcomes of Interventional Pain Procedures: A Retrospective Cohort Study.Cureus · 2026Article
- Pain Medicine and the Opioid Crisis: Time to Own Our Responsibility!European journal of pain (London, England) · 2026Article
- Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action.Pharmacology research & perspectives · 2026Review
- The bidirectional effects of hemorrhoids, depression, and anxiety: a prospective cohort study in the UK Biobank.Annals of general psychiatry · 2026Article
- Incidence and sociodemographic characteristics of coexisting function-limiting musculoskeletal problems and psychological distress among university students in Sweden: The SUN cohort study.BMJ public health · 2026Article
- Neuropathic Pain and Related Depression in Mice: The Effect of a Terpene and a Minor Cannabinoid in Combination.Biomedicines · 2025Article
- Obstructive Sleep Apnea Risk and Mental Health Conditions Among Older Canadian Adults in the Canadian Longitudinal Study on Aging.JAMA network open · 2025Article
- Cannabidiol and Beta-Caryophyllene: Chronic inflammatory pain.Pharmacological research · 2025Article
63 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The comorbidity of pain and depression has been well established in the literature and is associated with a greater burden to the individual and society than either condition alone. The relationship between pain and depression is quite complex and multiple factors must be considered when trying to disentangle the pain-depression link including shared neurobiology, precipitating environmental factors and cognitive influences. This article aims to provide an overview of the leading neurobiological and psychosocial theories that have advanced our understanding of the link between pain and depression. To this end we describe the shared neurobiological mechanisms in the brain thought to explain the overlap and consider psychological processes and how they inform a cognitive behavioral model. The article also provides an overview of the evidence based treatment for comorbid pain and depression.
Indexed as
Identifiers
24214740What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.