ArticleJournal of magnetic resonance imaging : JMRI2014
Quantification of amide proton transfer effect pre- and post-gadolinium contrast agent administration.
Article in Journal of magnetic resonance imaging : JMRI, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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Who cites it
18 citing papers in PubMed, 30 citations in OpenAlex.
- Mitigation of TRadiology advances · 2025Article
- Motion and magnetic field inhomogeneity correction techniques for chemical exchange saturation transfer (CEST) MRI: A contemporary review.NMR in biomedicine · 2025Review
- 3D amide proton transfer-weighted imaging may be useful for diagnosing early-stage breast cancer: a prospective monocentric study.European radiology experimental · 2024Article
- Multipool-CEST and CEST-based pH assessment as predictive tools for glioma grading, IDH mutation, 1p/19q codeletion, and MGMT promoter methylation in gliomas.Frontiers in oncology · 2024Article
- Review and consensus recommendations on clinical APT-weighted imaging approaches at 3T: Application to brain tumors.Magnetic resonance in medicine · 2022Review
- Clinical translation of amide proton transfer (APT) MRI for ischemic stroke: a systematic review (2003-2020).Quantitative imaging in medicine and surgery · 2021Review
- A comparative study of the value of amide proton transfer-weighted imaging and diffusion kurtosis imaging in the diagnosis and evaluation of breast cancer.European radiology · 2021Article
- Comparison of Diffusion Kurtosis Imaging and Amide Proton Transfer Imaging in the Diagnosis and Risk Assessment of Prostate Cancer.Frontiers in oncology · 2021Article
- Application of the amide proton transfer-weighted imaging and diffusion kurtosis imaging in the study of cervical cancer.European radiology · 2020Article
- Evaluating the Role of Amide Proton Transfer (APT)-Weighted Contrast, Optimized for Normalization and Region of Interest Selection, in Differentiation of Neoplastic and Infective Mass Lesions on 3T MRI.Molecular imaging and biology · 2020Article
- Motion correction of chemical exchange saturation transfer MRI series using robust principal component analysis (RPCA) and PCA.Quantitative imaging in medicine and surgery · 2019Article
- Amide proton transfer imaging seems to provide higher diagnostic performance in post-treatment high-grade gliomas than methionine positron emission tomography.European radiology · 2018Article
- Discriminating MGMT promoter methylation status in patients with glioblastoma employing amide proton transfer-weighted MRI metrics.European radiology · 2018Article
- Clinical applications of chemical exchange saturation transfer (CEST) MRI.Journal of magnetic resonance imaging : JMRI · 2018Review
- Amide Proton Transfer Imaging Allows Detection of Glioma Grades and Tumor Proliferation: Comparison with Ki-67 Expression and Proton MR Spectroscopy Imaging.AJNR. American journal of neuroradiology · 2017Article
- Selecting the reference image for registration of CEST series.Journal of magnetic resonance imaging : JMRI · 2016Article
- R1 correction in amide proton transfer imaging: indication of the influence of transcytolemmal water exchange on CEST measurements.NMR in biomedicine · 2015Article
- Comparing different analysis methods for quantifying the MRI amide proton transfer (APT) effect in hyperacute stroke patients.NMR in biomedicine · 2014Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
purposeTo compare quantification of the amide proton transfer (APT) effect pre- and post-gadolinium contrast agent (Gd) administration in order to establish to what extent Gd alters quantification of the APT effect. MATERIALS AND
methodsFour patients with internal carotid stenosis were recruited. APT imaging was acquired pre- and post-contrast in two sessions (before and after surgery) to assess the extent of relaxation time, T1 , change on APT effect calculated using magnetization transfer ratio asymmetry analysis at offsets of ±3.5 ppm relative to water resonance. Statistical and modeling evaluations were performed on the pre- and post-contrast APT effect to study the sensitivity to contrast administration.
resultsBefore surgery, the post-contrast T1 was estimated to drop <10% of the pre-value for the majority of the patients. After surgery, higher post-contrast T1 reductions were observed in all the patients (maximum decrease was about 20% of the pre-value). Consistent differences between pre- and post-contrast were seen in the APT effect quantified using the asymmetry measure in most regions of the brain, with significant differences found in the white matter at the group level and in 25% of the individual patient results.
conclusionAPT imaging should be performed prior to Gd administration to avoid potential misinterpretation of the APT effect.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.