ArticleThe Plant cell2013
Arabidopsis 56-amino acid serine palmitoyltransferase-interacting proteins stimulate sphingolipid synthesis, are essential, and affect mycotoxin sensitivity.
Article in The Plant cell, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 60 citations in OpenAlex.
- Transcriptomic and Physiological Profiling Elucidates Differential Salt Stress Responses in Tolerant 'SO4' and Sensitive 'Beida' Grapevine Rootstocks.International journal of molecular sciences · 2026Article
- Altered sphingolipid biosynthetic flux and lipoprotein trafficking contribute to trans-fat-induced atherosclerosis.Cell metabolism · 2025Article
- Trichothecenes and Fumonisins: Key Players inToxins · 2024Review
- Mechanism of sphingolipid homeostasis revealed by structural analysis ofScience advances · 2023Article
- Mysterious sphingolipids: metabolic interrelationships at the center of pathophysiology.Frontiers in physiology · 2023Review
- Fumonisin B1 as a Tool to Explore Sphingolipid Roles in Arabidopsis Primary Root Development.International journal of molecular sciences · 2022Article
- Cell death induced by mycotoxin fumonisin BPlant cell reports · 2022Article
- Sphingolipids are involved in insect egg-induced cell death in Arabidopsis.Plant physiology · 2022Article
- Sphingolipids at Plasmodesmata: Structural Components and Functional Modulators.International journal of molecular sciences · 2022Review
- Diversity in sphingolipid metabolism across land plants.Journal of experimental botany · 2022Review
- Serine Palmitoyltransferase Subunit 3 and Metabolic Diseases.Advances in experimental medicine and biology · 2022Review
- Sphingolipid metabolism, transport, and functions in plants: Recent progress and future perspectives.Plant communications · 2021Review
- Disruption of long-chain base hydroxylation alters growth and impacts sphingolipid synthesis inPlant direct · 2021Article
- Dissecting the regulatory roles of ORM proteins in the sphingolipid pathway of plants.PLoS computational biology · 2021Article
- Unregulated Sphingolipid Biosynthesis in Gene-Edited ArabidopsisThe Plant cell · 2020Article
- Subunit composition of the mammalian serine-palmitoyltransferase defines the spectrum of straight and methyl-branched long-chain bases.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The Lipid Flippases ALA4 and ALA5 Play Critical Roles in Cell Expansion and Plant Growth.Plant physiology · 2020Article
- Overexpression of FBR41 enhances resistance to sphinganine analog mycotoxin-induced cell death and Alternaria stem canker in tomato.Plant biotechnology journal · 2020Article
- Sphingolipids: towards an integrated view of metabolism during the plant stress response.The New phytologist · 2020Review
- Fumonisin B1: A Tool for Exploring the Multiple Functions of Sphingolipids in Plants.Frontiers in plant science · 2020Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Maintenance of sphingolipid homeostasis is critical for cell growth and programmed cell death (PCD). Serine palmitoyltransferase (SPT), composed of LCB1 and LCB2 subunits, catalyzes the primary regulatory point for sphingolipid synthesis. Small subunits of SPT (ssSPT) that strongly stimulate SPT activity have been identified in mammals, but the role of ssSPT in eukaryotic cells is unclear. Candidate Arabidopsis thaliana ssSPTs, ssSPTa and ssSPTb, were identified and characterized. Expression of these 56-amino acid polypeptides in a Saccharomyces cerevisiae SPT null mutant stimulated SPT activity from the Arabidopsis LCB1/LCB2 heterodimer by >100-fold through physical interaction with LCB1/LCB2. ssSPTa transcripts were more enriched in all organs and >400-fold more abundant in pollen than ssSPTb transcripts. Accordingly, homozygous ssSPTa T-DNA mutants were not recoverable, and 50% nonviable pollen was detected in heterozygous ssspta mutants. Pollen viability was recovered by expression of wild-type ssSPTa or ssSPTb under control of the ssSPTa promoter, indicating ssSPTa and ssSPTb functional redundancy. SPT activity and sensitivity to the PCD-inducing mycotoxin fumonisin B1 (FB1) were increased by ssSPTa overexpression. Conversely, SPT activity and FB1 sensitivity were reduced in ssSPTa RNA interference lines. These results demonstrate that ssSPTs are essential for male gametophytes, are important for FB1 sensitivity, and limit sphingolipid synthesis in planta.
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