ArticleThe Journal of comparative neurology2014
Longitudinal in vivo two-photon fluorescence imaging.
Article in The Journal of comparative neurology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed.
- NIR Excitation in Atomically Precise Nanoclusters via Two-Photon and Three-Photon Absorption.Accounts of chemical research · 2026Article
- Advances in Optical Contrast Agents for Medical Imaging: Fluorescent Probes and Molecular Imaging.Journal of imaging · 2025Review
- Linking brain activity across scales with simultaneous opto- and electrophysiology.Neurophotonics · 2024Review
- Green and sustainable fabrication of DES-pretreated high-strength densified wood.Wood science and technology · 2024Article
- Dendritic spine remodeling and plasticity under general anesthesia.Brain structure & function · 2021Review
- Prefrontal deep projection neurons enable cognitive flexibility via persistent feedback monitoring.Cell · 2021Article
- Structural synaptic plasticity across sleep and wake.Current opinion in physiology · 2020Review
- Dual-Component Structural Plasticity Mediated by αCaMKII Autophosphorylation on Basal Dendrites of Cortical Layer 2/3 Neurones.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Investigating learning-related neural circuitry with chronic in vivo optical imaging.Brain structure & function · 2020Review
- Two-photon probes for in vivo multicolor microscopy of the structure and signals of brain cells.Brain structure & function · 2018Review
- Stable Sequential Activity Underlying the Maintenance of a Precisely Executed Skilled Behavior.Neuron · 2018Article
- Two-Photon Uncaging of Glutamate.Frontiers in synaptic neuroscience · 2018Review
- Subcellular spatial resolution achieved for deep-brain imaging in vivo using a minimally invasive multimode fiber.Light, science & applications · 2018Article
- Lynx1 Limits Dendritic Spine Turnover in the Adult Visual Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- TRIO Platform: A Novel Low Profile In vivo Imaging Support and Restraint System for Mice.Frontiers in neuroscience · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Fluorescence microscopy is an essential technique for the basic sciences, especially biomedical research. Since the invention of laser scanning confocal microscopy in the 1980s, which enabled imaging both fixed and living biological tissue with 3D precision, high-resolution fluorescence imaging has revolutionized biological research. Confocal microscopy, by its very nature, has one fundamental limitation. Due to the confocal pinhole, deep tissue fluorescence imaging is not practical. In contrast (no pun intended), two-photon fluorescence microscopy allows, in principle, the collection of all emitted photons from fluorophores in the imaged voxel, dramatically extending our ability to see deep into living tissue. Since the development of transgenic mice with genetically encoded fluorescent protein in neocortical cells in 2000, two-photon imaging has enabled the dynamics of individual synapses to be followed for up to 2 years. Since the initial landmark contributions to this field in 2002, the technique has been used to understand how neuronal structure are changed by experience, learning, and memory and various diseases. Here we provide a basic summary of the crucial elements that are required for such studies, and discuss many applications of longitudinal two-photon fluorescence microscopy that have appeared since 2002.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.