ReviewPediatric blood & cancer2014
Novel molecular pathways in Gorham disease: implications for treatment.
Review in Pediatric blood & cancer, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Complex lymphatic anomalies.Pediatric radiology · 2025Review
- Exploring the genetic alterations of Gorham-Stout disease.Frontiers in endocrinology · 2025Review
- The molecular mechanism of Gorham syndrome: an update.Frontiers in immunology · 2023Review
- Thoracic Gorham-Stout disease masquerading as an ovarian malignancy: a differential diagnosis in non-malignant causes of raised Ca-125 and overview of this rare pathology.BMJ case reports · 2022Article
- Difficult Therapeutic Decisions in Gorham-Stout Disease-Case Report and Review of the Literature.International journal of environmental research and public health · 2022Review
- Daratumumab, Lenalidomide, and Dexamethasone (DRD), an Active Regimen in the Treatment of Immunosuppression-Associated Plasmablastic Lymphoma (PBL) in the Setting of Gorham's Lymphangiomatosis: Review of the Literature.Case reports in hematology · 2022Article
- Predisposing conditions for bacterial meningitis in children: what radiologists need to know.Japanese journal of radiology · 2022Review
- A Rare Case of Vanishing Bone Disease of Metacarpals.Journal of orthopaedic case reports · 2021Article
- Stimulation of Treg Cells to Inhibit Osteoclastogenesis in Gorham-Stout Disease.Frontiers in cell and developmental biology · 2021Article
- Observational
- Gorham-Stout disease successfully treated with sirolimus (rapamycin): a case report and review of the literature.BMC musculoskeletal disorders · 2020Review
- A Large Skull Defect Due to Gorham-Stout Disease: Case Report and Literature Review on Pathogenesis, Diagnosis, and Treatment.Frontiers in endocrinology · 2020Review
- Gorham-Stout disease in the rib and thoracic spine with spinal injury treated with radiotherapy, zoledronic acid, vitamin D, and propranolol: A case report and literature review.Molecular and clinical oncology · 2019Article
- The First Clinical Case of Gorham-Stout Syndrome of Humerus in an 18-year-old Female Reported in Pakistan.Cureus · 2019Article
- Generalized Lymphatic Anomaly and Gorham-Stout Disease: Overview and Recent Insights.Advances in wound care · 2019Review
- Massive Axial and Appendicular Skeletal Deformities in Connection with Gorham-Stout Syndrome.Medicines (Basel, Switzerland) · 2019Article
- Article
- Gorham-Stout disease of the pelvis: Seven years follow up with complete radiological evaluation.Journal of musculoskeletal & neuronal interactions · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
Rapid advances in evidence-based treatment schedules are a hallmark of modern oncology. In rare neoplastic diseases, however, clinical expertise is hard to build and evidence based on randomized trials almost impossible to collect. Gorham disease is a rare form of lymphatic proliferation accompanied by osteolysis, which usually occurs in young adults. Despite the fact that the clinical course of Gorham disease is often devastating and occasionally fatal, insights into its biological background are sparse and standardized treatment unavailable. Interestingly, recent knowledge on the mechanisms of lymphangiogenesis may help elucidate the pathophysiology of Gorham disease and lead to novel treatment targets. Here, we discuss our current understanding of Gorham disease, discuss established and emerging therapeutic strategies, and attempt to frame a treatment rationale.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.