ReviewImmunologic research2013
Neonatal immunology: responses to pathogenic microorganisms and epigenetics reveal an "immunodiverse" developmental state.
Review in Immunologic research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- T cells in the brain enhance neonatal mortality during peripheral LCMV infection.PLoS pathogens · 2021Article
- Age-related changes in PD-1 expression coincide with increased cytotoxic potential in Vδ2 T cells during infancy.Cellular immunology · 2021Article
- The Power of First Impressions: Can Influenza Imprinting during Infancy Inform Vaccine Design?Vaccines · 2020Review
- Maturation of the Acute Hepatic TLR4/NF-κB Mediated Innate Immune Response Is p65 Dependent in Mice.Frontiers in immunology · 2020Article
- The Profile of Human Milk Metabolome, Cytokines, and Antibodies in Inflammatory Bowel Diseases Versus Healthy Mothers, and Potential Impact on the Newborn.Journal of Crohn's & colitis · 2019Article
- Developmentally Regulated Innate Immune NFκB Signaling Mediates IL-1α Expression in the Perinatal Murine Lung.Frontiers in immunology · 2019Article
- Transcriptome analysis of immune genes in peripheral blood mononuclear cells of young foals and adult horses.PloS one · 2018Article
- Decreased production of class-switched antibodies in neonatal B cells is associated with increased expression of miR-181b.PloS one · 2018Article
- Immunotolerant p50/NFκB Signaling and Attenuated Hepatic IFNβ Expression Increases Neonatal Sensitivity to Endotoxemia.Frontiers in immunology · 2018Article
- Tolerance and immunity to pathogens in early life: insights from HBV infection.Seminars in immunopathology · 2017Review
- Maternal and pregnancy-related factors affecting human milk cytokines among Peruvian mothers bearing low-birth-weight neonates.Journal of reproductive immunology · 2017Article
- Genomic Programming of Human Neonatal Dendritic Cells in Congenital Systemic andFrontiers in immunology · 2017Article
- Circulating Inflammatory-Associated Proteins in the First Month of Life and Cognitive Impairment at Age 10 Years in Children Born Extremely Preterm.The Journal of pediatrics · 2017Article
- Neonatal NET-inhibitory factor and related peptides inhibit neutrophil extracellular trap formation.The Journal of clinical investigation · 2016Article
- Prolonged PD1 Expression on Neonatal Vδ2 Lymphocytes Dampens Proinflammatory Responses: Role of Epigenetic Regulation.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Neonatal monocytes exhibit a unique histone modification landscape.Clinical epigenetics · 2016Article
- Clearance of Pneumococcal Colonization in Infants Is Delayed through Altered Macrophage Trafficking.PLoS pathogens · 2015Article
- What Causes Biliary Atresia? Unique Aspects of the Neonatal Immune System Provide Clues to Disease Pathogenesis.Cellular and molecular gastroenterology and hepatology · 2015Article
- Systems approach to the study of brain damage in the very preterm newborn.Frontiers in systems neuroscience · 2015Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Neonatal animals have heightened susceptibility to infectious agents and are at increased risk for the development of allergic diseases, such as asthma. Experimental studies using animal models have been quite useful for beginning to identify the cellular and molecular mechanisms underlying these sensitivities. In particular, results from murine neonatal models indicate that developmental regulation of multiple immune cell types contributes to the typically poor responses of neonates to pathogenic microorganisms. Surprisingly, however, animal studies have also revealed that responses at mucosal surfaces in early life may be protective against primary or secondary disease. Our understanding of the molecular events underlying these processes is less well developed. Emerging evidence indicates that the functional properties of neonatal immune cells and the subsequent maturation of the immune system in ontogeny may be regulated by epigenetic phenomena. Here, we review recent findings from our group and others describing cellular responses to infection and developmentally regulated epigenetic processes in the newborn.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.