ArticleJournal of molecular histology2014
Protective effect of lycopene on cardiac function and myocardial fibrosis after acute myocardial infarction in rats via the modulation of p38 and MMP-9.
Article in Journal of molecular histology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 38 citations in OpenAlex.
- Foam Cells: The Origin of Formation and Target for Plant-derived Bioactive Compounds.Current medicinal chemistry · 2026Review
- Pharmacological potentials of lycopene against aging and aging-related disorders: A review.Food science & nutrition · 2023Review
- Lycopene: a therapeutic strategy against coronavirus disease 19 (COVID- 19).Inflammopharmacology · 2022Review
- Cardiovascular Disease and Possible Ways in Which Lycopene Acts as an Efficient Cardio-Protectant against Different Cardiovascular Risk Factors.Molecules (Basel, Switzerland) · 2022Review
- Lycopene in the Prevention of Cardiovascular Diseases.International journal of molecular sciences · 2022Review
- Effects of Lycopene Attenuating Injuries in Ischemia and Reperfusion.Oxidative medicine and cellular longevity · 2022Review
- Article
- MiR-124 Regulates the Inflammation and Apoptosis in Myocardial Infarction Rats by Targeting STAT3.Cardiovascular toxicology · 2021Article
- The effect of lycopene on serum level of cardiac biomarkers in patients undergoing elective percutaneous coronary intervention: A randomized controlled clinical trial.ARYA atherosclerosis · 2021Article
- Computational model predicts paracrine and intracellular drivers of fibroblast phenotype after myocardial infarction.Matrix biology : journal of the International Society for Matrix Biology · 2020Review
- The Role of Matrix Metalloproteinase-9 in Atherosclerotic Plaque Instability.Mediators of inflammation · 2020Review
- Cardioprotective Effects of Nanoemulsions Loaded with Anti-Inflammatory Nutraceuticals against Doxorubicin-Induced Cardiotoxicity.Nutrients · 2018Article
- Lycopene and Vascular Health.Frontiers in pharmacology · 2018Review
- Effects of neuregulin-1 on autonomic nervous system remodeling post-myocardial infarction in a rat model.Neural regeneration research · 2017Article
- High mobility group box 1 protein attenuates myocardial ischemia reperfusion injury via inhibition of the p38 mitogen-activated protein kinase signaling pathway.Experimental and therapeutic medicine · 2017Article
- Article
- Inhibitory effect of microRNA-21 on pathways and mechanisms involved in cardiac fibrosis development.Therapeutic advances in cardiovascular diseaseReview
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Extracellular matrix (ECM) plays an important role in maintaining the left ventricular geometry and ventricular function, and the inhibition of ECM remodeling has therapeutic benefits that could alleviate the progression of ventricular remodeling. Recent studies have indicated that lycopene has cardioprotective effects. In this study, a rat myocardial infarction (MI) model was established by left anterior descending coronary artery ligation. After the operation, the rats received lycopene or saline. After 28 days, the rats underwent echocardiography detection and were sacrificed. Myocardial fibrosis was observed by Masson staining. Type I collagen, MMP-9, and MAPK protein expression were detected in the ischemic zone surrounding the MI by western blot. Treatment with lycopene increased the EF from 45.2 ± 3.12 % to 51.1 ± 4.63, and it decreased the LVEDd from 6.52 ± 0.37 mm to 6.18 ± 0.41 mm and the LVESd from 4.29 ± 0.63 to 3.94 ± 0.37 at 28 days post-myocardial infarction. Lycopene attenuated the MI-induced increase in MMP-9 and type I collagen expression, and inhibited p38 activation. Moreover, lycopene decreased the collagen volume fraction in the peri-infarcted zone. The data indicated that lycopene improved the cardiac function and ventricular remodeling by inhibiting p38 activation and MMP-9 expression.
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