ArticleEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2014
Genetic and phenotypic analysis of Vibrio cholerae non-O1, non-O139 isolated from German and Austrian patients.
Article in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed, 72 citations in OpenAlex.
- Microbiota shows major difference in case of two shorebird species with different feeding strategy.Veterinary and animal science · 2026Article
- Virulence gene profiles and antimicrobial resistance in clinical and environmental isolates of Non-O1/Non-O139 Vibrio cholerae.BMC microbiology · 2026Article
- Population structure and phylogenetic analysis of Vibrio cholerae non-O1/O139 by whole genome sequencing.PloS one · 2026Article
- Non-O1/O139 environmental Vibrio cholerae from Northern Cameroon reveals potential intra-/inter-continental transmissions.PLoS neglected tropical diseases · 2025Article
- Public health aspects ofEFSA journal. European Food Safety Authority · 2024Article
- Non-O1/Non-O139Microorganisms · 2024Review
- Combined TCBS and CHROMagar Analyses Allow for Basic Identification ofMicroorganisms · 2024Article
- Genetic and Phenotypic Virulence Potential of Non-O1/Non-O139Microorganisms · 2023Article
- Vibrio cholerae-An emerging pathogen in Austrian bathing waters?Wiener klinische Wochenschrift · 2023Review
- ToxigenicApplied and environmental microbiology · 2023Article
- Occurrence of virulence determinants in vibrio cholerae, vibrio mimicus, vibrio alginolyticus, and vibrio parahaemolyticus isolates from important water resources of Eastern Cape, South Africa.BMC microbiology · 2023Article
- Evidence of Antibiotic Resistance and Virulence Factors in Environmental Isolates ofAntibiotics (Basel, Switzerland) · 2023Article
- Virulence and resistance patterns ofFrontiers in microbiology · 2023Article
- Article
- Epidemiological and microbiological investigation of a large increase in vibriosis, northern Europe, 2018.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022Article
- Non-serogroup O1/O139 agglutinable Vibrio cholerae: a phylogenetically and genealogically neglected yet emerging potential pathogen of clinical relevance.Archives of microbiology · 2022Review
- Prevalence and Distribution of Potentially Human PathogenicFrontiers in cellular and infection microbiology · 2022Article
- Population Structure and Multidrug Resistance of Non-O1/Non-O139 Vibrio cholerae in Freshwater Rivers in Zhejiang, China.Microbial ecology · 2021Article
- Virulence of Cholera Toxin Gene-PositiveFrontiers in microbiology · 2021Article
- Virulence and Antibiotic Resistance Characteristics ofFrontiers in cellular and infection microbiology · 2021Article
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vibrio cholerae belonging to the non-O1, non-O139 serogroups are present in the coastal waters of Germany and in some German and Austrian lakes. These bacteria can cause gastroenteritis and extraintestinal infections, and are transmitted through contaminated food and water. However, non-O1, non-O139 V. cholerae infections are rare in Germany. We studied 18 strains from German and Austrian patients with diarrhea or local infections for their virulence-associated genotype and phenotype to assess their potential for infectivity in anticipation of possible climatic changes that could enhance the transmission of these pathogens. The strains were examined for the presence of genes encoding cholera toxin and toxin-coregulated pilus (TCP), as well as other virulence-associated factors or markers, including hemolysins, repeats-in-toxin (RTX) toxins, Vibrio seventh pandemic islands VSP-1 and VSP-2, and the type III secretion system (TTSS). Phenotypic assays for hemolysin activity, serum resistance, and biofilm formation were also performed. A dendrogram generated by incorporating the results of these analyses revealed genetic differences of the strains correlating with their clinical origin. Non-O1, non-O139 strains from diarrheal patients possessed the TTSS and/or the multifunctional autoprocessing repeats-in-toxin (MARTX) toxin, which were not found in the strains from ear or wound infections. Routine matrix-assisted laser desorption/ionization (MALDI-TOF) mass spectrometry (MS) analysis of all strains provided reliable identification of the species but failed to differentiate between strains or clusters. The results of this study indicate the need for continued surveillance of V. cholerae non-O1, non-O139 in Germany, in view of the predicted increase in the prevalence of Vibrio spp. due to the rise in surface water temperatures.
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