ReviewMolecular and cellular biochemistry2014
Nutriepigenetic regulation by folate-homocysteine-methionine axis: a review.
Review in Molecular and cellular biochemistry, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Serum Homocysteine Could Be Used as a Predictive Marker for Chronic Obstructive Pulmonary Disease: A Meta-Analysis.Frontiers in public health · 2019Pooled it
- Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency.PloS one · 2016Trial
- One-carbon metabolism and cardiovascular disease: Molecular mechanisms, genetic influences, and epigenetic regulation.Biochemistry and biophysics reports · 2026Review
- The role of chrysanthemum phytochemicals in neural tube development: a narrative review of underlying mechanisms.Frontiers in cell and developmental biology · 2026Review
- Influence of APOE4 Genotypes on Nutrient-Cognition Relationship in Taiwanese Older Adults: Longitudinal Findings from the HALST.Nutrients · 2025Observational
- Hyperhomocysteinaemia aggravates periodontitis by suppressing the Nrf2/HO-1 signalling pathway.Redox report : communications in free radical research · 2025Article
- Association between red blood cell folate and accelerated aging in American adults: a cross-sectional study from the national health and nutrition examination survey.Frontiers in nutrition · 2025Article
- Mendelian randomization study to investigate the causal relationship between plasma homocysteine and chronic obstructive pulmonary disease.World journal of emergency medicine · 2023Article
- The Role of the Paraventricular-Coerulear Network on the Programming of Hypertension by Prenatal Undernutrition.International journal of molecular sciences · 2022Review
- Micronutrient Deficiencies and Anemia in Urban India-Do We Need Food Fortification?Indian journal of clinical biochemistry : IJCB · 2022Article
- Article
- Foveal macular pigment dip in offspring of age-related macular degeneration patients is inversely associated with omega-3 index.BMC ophthalmology · 2020Article
- Influence of Sulfonamide Contamination Derived from Veterinary Antibiotics on Plant Growth and Development.Antibiotics (Basel, Switzerland) · 2020Article
- The association of maternal plant-based diets and the growth of breastfed infants.Health promotion perspectives · 2020Article
- Comparison of different types of twin pregnancies in terms of obstetric and perinatal outcomes: association of vanished twins with methylenetetrahydrofolate reductase (MTHFR) polymorphism(s).Journal of assisted reproduction and genetics · 2018Article
- Methylenetetrahydrofolate Reductase Polymorphisms and Pregnancy Outcome.Geburtshilfe und Frauenheilkunde · 2018Article
- Article
- Spinal cord demyelination combined with hyperhomocysteinemia: a case report.Neuropsychiatric disease and treatment · 2014Article
- Maternal methyl donors supplementation during lactation prevents the hyperhomocysteinemia induced by a high-fat-sucrose intake by dams.International journal of molecular sciences · 2013Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although normally folic acid is given during pregnancy, presumably to prevent neural tube defects, the mechanisms of this protection are unknown. More importantly it is unclear whether folic acid has other function during development. It is known that folic acid re-methylates homocysteine (Hcy) to methionine by methylene tetrahydrofolate reductase-dependent pathways. Folic acid also generates high-energy phosphates, behaves as an antioxidant and improves nitric oxide (NO) production by endothelial NO synthase. Interestingly, during epigenetic modification, methylation of DNA/RNA generate homocysteine unequivocally. The enhanced overexpression of methyl transferase lead to increased yield of Hcy. The accumulation of Hcy causes vascular dysfunction, reduces perfusion in the muscles thereby causing musculopathy. Another interesting fact is that children with severe hyperhomocysteinaemia (HHcy) have skeletal deformities, and do not live past teenage. HHcy is also associated with the progeria syndrome. Epilepsy is primarily caused by inhibition of gamma-amino-butyric-acid (GABA) receptor, an inhibitory neurotransmitter in the neuronal synapse. Folate deficiency leads to HHcy which then competes with GABA for binding on the GABA receptors. With so many genetic and clinical manifestations associated with folate deficiency, we propose that folate deficiency induces epigenetic alterations in the genes and thereby results in disease.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.