ArticleEuropean journal of nuclear medicine and molecular imaging2014
Impact of scar on SPECT assay of left ventricular contraction dyssynchrony.
Article in European journal of nuclear medicine and molecular imaging, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Prognostic significance of phase analysis using SPECT myocardial perfusion imaging in heart failure: a systematic review and meta-analysis.The international journal of cardiovascular imaging · 2025Pooled it
- The value of cardiac sympathetic activity and mechanical dyssynchrony as cardiac resynchronization therapy response predictors: comparison between patients with ischemic and non-ischemic heart failure.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Prediction of Cardiac Resynchronization Therapy Response Using Quantitative Gated Myocardial Perfusion Imaging.The Journal of innovations in cardiac rhythm management · 2023Article
- Predictive values of left ventricular mechanical dyssynchrony for CRT response in heart failure patients with different pathophysiology.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Article
- A Mild Dyssynchronous Contraction Pattern Detected by SPECT Myocardial Perfusion Imaging Predicts Super-Response to Cardiac Resynchronization Therapy.Frontiers in cardiovascular medicine · 2022Article
- Myocardial ischemia and previous infarction contribute to left ventricular dyssynchrony in patients with coronary artery disease.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Left-ventricular dyssynchrony in viable myocardium by myocardial perfusion SPECT is predictive of mechanical response to CRT.Annals of nuclear medicine · 2021Article
- Incremental Value of Left Ventricular Mechanical Dyssynchrony Assessment by Nitrogen-13 Ammonia ECG-Gated PET in Patients With Coronary Artery Disease.Frontiers in cardiovascular medicine · 2021Article
- Is myocardial viability related to left ventricular dyssynchrony?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Could myocardial viability be related to left ventricular dyssynchrony? Simultaneous evaluation by gated SPECT-MPI.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Left ventricular mechanical dyssynchrony for CAD diagnosis: Does it have incremental clinical values?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Article
- Prognostic Value of Early Evaluation of Left Ventricular Dyssynchrony After Myocardial Infarction.Molecular imaging and biology · 2019Article
- Myocardial stunning-induced left ventricular dyssynchrony on gated single-photon emission computed tomography myocardial perfusion imaging.Nuclear medicine communications · 2018Article
- Nuclear image-guided left ventricular pacing lead navigation feasibility of a new technique.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2015Article
- Is there an association between hibernating myocardium and left ventricular mechanical dyssynchrony in patients with myocardial infarction?Hellenic journal of nuclear medicineArticle
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Authors and funding
4 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeMany patients presently receiving cardiac resynchronization therapy (CRT) do not respond. A disproportionate number of nonresponders have ischemic cardiomyopathy, with significant left ventricular (LV) scar burden. Current selection criteria, such as electrocardiography or echocardiography, may not reliably portray the magnitude of CRT-remediable LV contraction dyssynchrony. Although phase analysis of gated single photon emission computed tomography (SPECT) image data is increasingly appreciated as a tool for quantifying dyssynchrony, its use in the setting of scar has not been adequately evaluated.
methodsConsecutive patients with ischemic (ICM, n = 50) or nonischemic (NICM, n = 39) cardiomyopathy underwent SPECT imaging prior to receiving CRT. In each patient, phase analysis of the raw images was performed to yield a phase standard deviation (PSD), an index which varies directly with the magnitude of dyssynchrony. ICM patient image data were also reanalyzed after scarred segments were stripped away.
resultsRaw image analysis demonstrated that PSD was significantly larger among ICM (57 ± 17°) than NICM (35 ± 13°, p < 0.001) patients. Among ICM patients, PSD after stripping of scarred segments was significantly decreased (40 ± 13°, p < 0.001). Signals emanating from scarred segments were of low amplitude and presented a random pattern, suggestive of noise rather than indicating contraction.
conclusionPSD values may be spuriously increased by scar. These findings may be important when using SPECT in selecting ischemic cardiomyopathy patients for CRT.
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