ArticlePlant cell reports2014
The role of hexokinases from grape berries (Vitis vinifera L.) in regulating the expression of cell wall invertase and sucrose synthase genes.
Article in Plant cell reports, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 48 citations in OpenAlex.
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- Enhanced growth and productivity of useful metabolites by indole-3-propionic acid treatment in Lemna aequinoctialis culture.BMC plant biology · 2025Article
- From acidity to sweetness: a comprehensive review of carbon accumulation in grape berries.Molecular horticulture · 2024Review
- The critical roles of three sugar-related proteins (HXK, SnRK1, TOR) in regulating plant growth and stress responses.Horticulture research · 2024Article
- Fruit Photosynthesis: More to Know about Where, How and Why.Plants (Basel, Switzerland) · 2023Review
- Characterization of hexokinase gene family members inFrontiers in genetics · 2023Article
- Insights into sugar metabolism during bilberry (Vaccinium myrtillus L.) fruit development.Physiologia plantarum · 2022Article
- Transcriptional profiling of two muscadine grape cultivars "Carlos" and "Noble" to reveal new genes, gene regulatory networks, and pathways that involved in grape berry ripening.Frontiers in plant science · 2022Article
- Quantitative Ubiquitylomic Analysis of the Dynamic Changes and Extensive Modulation of Ubiquitylation in Papaya During the Fruit Ripening Process.Frontiers in plant science · 2022Article
- Light Microclimate-Driven Changes at Transcriptional Level in Photosynthetic Grape Berry Tissues.Plants (Basel, Switzerland) · 2021Article
- Comparative transcriptome analysis of Rheum australe, an endangered medicinal herb, growing in its natural habitat and those grown in controlled growth chambers.Scientific reports · 2021Article
- Early-stage sugar beet taproot development is characterized by three distinct physiological phases.Plant direct · 2020Article
- Isolation and characterization of hexokinase genes PsHXK1 and PsHXK2 from tree peony (Paeonia suffruticosa Andrews).Molecular biology reports · 2020Article
- The Molecular Regulation of Carbon Sink Strength in Grapevine (Frontiers in plant science · 2020Review
- Polysaccharide biosynthetic pathway profiling and putative gene mining of Dendrobium moniliforme using RNA-Seq in different tissues.BMC plant biology · 2019Article
- Article
- Infection of post-harvest peaches byHorticulture research · 2018Article
- Article
- Structure, Expression, and Functional Analysis of the Hexokinase Gene Family in Cassava.International journal of molecular sciences · 2017Article
- Grape hexokinases are involved in the expression regulation of sucrose synthase- and cell wall invertase-encoding genes by glucose and ABA.Plant molecular biology · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In plants, hexokinase (HXK, EC 2.7.1.1) involved in hexose phosphorylation, plays an important role in sugar sensing and signaling. In this study, we found that at Phase I of grape berry development, lower hexose (glucose or fructose) levels were concomitant with higher HXK activities and protein levels. After the onset of ripening, we demonstrated a drastic reduction in HXK activity and protein levels accompanied by a rising hexose level. Therefore, our results revealed that HXK activity and protein levels had an inverse relationship with the endogenous glucose or fructose levels during grape berry development. A 51 kDa HXK protein band was detected throughout grape berry development. In addition, HXK located in the vacuoles, cytoplasm, nucleus, proplastid, chloroplast, and mitochondrion of the berry flesh cells. During grape berry development, HXK transcriptional level changed slightly, while cell wall invertase (CWINV) and sucrose synthase (SuSy) expression was enhanced after véraison stage. Intriguingly, when sliced grape berries were incubated in different glucose solutions, CWINV and SuSy expression was repressed by glucose, and the intensity of repression depended on glucose concentration and incubation time. After sliced, grape berries were treated with different glucose analogs, CWINV and SuSy expression analyses revealed that phosphorylation of hexoses by hexokinase was an essential component in the glucose-dependent CWINV and SuSy expression. In the meantime, mannoheptulose, a specific inhibitor of hexokinase, blocked the repression induced by glucose on CWINV and SuSy expression. It suggested that HXK played a major role in regulating CWINV and SuSy expression during grape berry development.
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