ArticleMolecular genetics and genomics : MGG2014
Fine mapping and epistatic interactions of the vernalization gene VRN-D4 in hexaploid wheat.
Article in Molecular genetics and genomics : MGG, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Optimizing wheat development to a range of winter climates.Journal of experimental botany · 2026Review
- O-GlcNAc and phosphorylation modifications on HtL1/FBA10 regulate wheat vernalization for flowering.Nature communications · 2025Article
- Improving genomic selection in hexaploid wheat with sub-genome additive and epistatic models.G3 (Bethesda, Md.) · 2025Article
- Genome-wide identification and expression analysis of TaFDL gene family responded to vernalization in wheat (Triticum aestivum L.).BMC genomics · 2025Article
- Molecular genetic regulation of the vegetative-generative transition in wheat from an environmental perspective.Annals of botany · 2025Review
- Unraveling the Secrets of Early-Maturity and Short-Duration Bread Wheat in Unpredictable Environments.Plants (Basel, Switzerland) · 2024Review
- QTL Mapping of Yield-Related Traits in Tetraploid Wheat Based on Wheat55K SNP Array.Plants (Basel, Switzerland) · 2024Article
- Identification and map-based cloning of an EMS-induced mutation in wheat gene TaSP1 related to spike architecture.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2024Article
- Analysis of the Structural Organization and Expression of thePlants (Basel, Switzerland) · 2023Article
- Fine mapping and genetic analysis identified a CTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2023Article
- QTL Mapping for Important Agronomic Traits Using a Wheat55K SNP Array-Based Genetic Map in Tetraploid Wheat.Plants (Basel, Switzerland) · 2023Article
- Transcriptome profiling of developing leaf and shoot apices to reveal the molecular mechanism and co-expression genes responsible for the wheat heading date.BMC genomics · 2021Article
- Phenology and related traits for wheat adaptation.Heredity · 2020Review
- Gene regulatory network and abundant genetic variation play critical roles in heading stage of polyploidy wheat.BMC plant biology · 2019Review
- Single nucleotide polymorphisms in a regulatory site of VRN-A1 first intron are associated with differences in vernalization requirement in winter wheat.Molecular genetics and genomics : MGG · 2018Article
- A population of wheat multiple synthetic derivatives: an effective platform to explore, harness and utilize genetic diversity of Aegilops tauschii for wheat improvement.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Article
- Fine Mapping of a Novel Heading Date Gene,Frontiers in plant science · 2018Article
- Identification of vernalization responsive genes in the winter wheat cultivar Jing841 by transcriptome sequencing.Journal of genetics · 2016Article
- Improvement of Predictive Ability by Uniform Coverage of the Target Genetic Space.G3 (Bethesda, Md.) · 2016Article
- Development and characterization of a spring hexaploid wheat line with no functional VRN2 genes.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2016Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wheat vernalization requirement is mainly controlled by the VRN1, VRN2, VRN3, and VRN4 genes. The first three have been cloned and have homoeologs in all three genomes. VRN4 has been found only in the D genome (VRN-D4) and has not been cloned. We constructed a high-density genetic map of the VRN-D4 region and mapped VRN-D4 within a 0.09 cM interval in the centromeric region of chromosome 5D. Using telocentric 5D chromosomes generated from the VRN-D4 donor Triple Dirk F, we determined that VRN-D4 is located on the short arm. The VRN-D4 candidate region is colinear with a 2.24 Mb region on Brachypodium distachyon chromosome 4, which includes 127 predicted genes. Ten of these genes have predicted roles in development but we detected no functional polymorphisms associated to VRN-D4. Two recombination events separated VRN-D4 from TaVIL-D1, the wheat homolog of Arabidopsis vernalization gene VIL1, confirming that this gene is not a candidate for VRN-D4. We detected significant interactions between VRN-D4 and other four genes controlling vernalization requirement (Vrn-A1, Vrn-B1, Vrn-D1, and Vrn-B3), which confirmed that VRN-D4 is part of the vernalization pathway and that it is either upstream or is part of the regulatory feedback loop involving VRN1, VRN2 and VRN3 genes. The precise mapping of VRN-D4 and the characterization of its interactions with other vernalization genes provide valuable information for the utilization of VRN-D4 in wheat improvement and for our current efforts to clone this vernalization gene.
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