Evidence map›Paper›PMID 24213369›Full record

Trial reportThe Journal of investigative dermatology2014

Reduction in serine protease activity correlates with improved rosacea severity in a small, randomized pilot study of a topical serine protease inhibitor.

Aimee M Two, Tissa R Hata, Teruaki Nakatsuji, Alvin B Coda, Paul F Kotol, Wiggin Wu, Faiza Shafiq, Eugene Y Huang, Richard L Gallo

Open access · bronzeAbstract readLetterRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The Journal of investigative dermatology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 2 pooled it
4.5field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 44 citations in OpenAlex.

  1. Pooled it
  2. Interventions for rosacea.The Cochrane database of systematic reviews · 2015
    Pooled it
  3. Review
  4. Article
  5. Review
  6. Review
  7. Review
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Rosacea Management.Skin appendage disorders · 2016
    Review
  14. Review
  15. Article
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Aimee M TwoDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Tissa R HataDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Teruaki NakatsujiDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Alvin B CodaDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Paul F KotolDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Wiggin WuDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Faiza ShafiqDivision of Dermatology, University of California San Diego, San Diego, California, USA.
Eugene Y HuangDivision of Dermatology, University of California San Diego, San Diego, California, USA; Therapeutics Clinical Research, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA.
Richard L GalloDivision of Dermatology, University of California San Diego, San Diego, California, USA; Skin EpiBiotics Inc., San Diego, California, USA. Electronic address: rgallo@ucsd.edu.
University of California San Diego · US

Funding

Proteolysis and Skin AntimicrobialsR01AR052728 · NIAMS · VETERANS MEDICAL RESEARCH FDN/SAN DIEGO · PI GALLO, RICHARD L · 2006 to 2015
$3.3M
Skin Microbiome in epidermal immune defenseR01AI083358 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GALLO, RICHARD L · 2010 to 2014
$1.9M
NIAID NIH HHS R01 AI083358NIAMS NIH HHS R01 AR052728NIAMS NIH HHS R01-AR052728
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Administration, TopicalAdultAgedAged, 80 and overAminocaproic AcidAntimicrobial Cationic PeptidesAprotininCathelicidinsDouble-Blind MethodFemaleGene Expression Regulation, EnzymologicHumansInflammationKallikreinsMaleMiddle AgedAminocaproic AcidAntimicrobial Cationic PeptidesAprotininCathelicidinsKallikreinsKLK5 protein, humanPeptide HydrolasesSerine ProteasesSerine Proteinase InhibitorsTrypsin

Identifiers

PMID24213369
PMCPMC3970953
OpenAlexW2154002519

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.