ArticleVirchows Archiv : an international journal of pathology2013
Superficial EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion: a new variant of Ewing-like tumors with locoregional lymph node metastasis.
Article in Virchows Archiv : an international journal of pathology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- CIC-DUX4 Sarcoma of the Skin: A Rare Case Report and Literature Review.Journal of cutaneous pathology · 2025Review
- Molecular and therapeutic advancements in Capicua (Frontiers in cell and developmental biology · 2024Review
- A case report ofFrontiers in oncology · 2022Article
- Round Cell Sarcoma with EWSR1-PATZ1 Fusion in the Face of a Five-Year-Old Boy: Report of a Case with Unusual Histologic Features.Head and neck pathology · 2021Article
- Fusion genes as biomarkers in pediatric cancers: A review of the current state and applicability in diagnostics and personalized therapy.Cancer letters · 2021Review
- Clinicopathologic features of undifferentiated round cell sarcomas of bone & soft tissues: An attempt to unravel theThe Indian journal of medical research · 2019Article
- [Round-cell sarcomas].Der Pathologe · 2019Review
- CIC fusion-positive sarcoma of the spermatic cord.Virchows Archiv : an international journal of pathology · 2019Article
- Article
- ETV transcriptional upregulation is more reliable than RNA sequencing algorithms and FISH in diagnosing round cell sarcomas with CIC gene rearrangements.Genes, chromosomes & cancer · 2017Article
- Histological and immunohistochemical characteristics of undifferentiated small round cell sarcomas associated with CIC-DUX4 and BCOR-CCNB3 fusion genes.Virchows Archiv : an international journal of pathology · 2017Article
- A new mode of DNA binding distinguishes Capicua from other HMG-box factors and explains its mutation patterns in cancer.PLoS genetics · 2017Article
- Targeted next-generation sequencing of CIC-DUX4 soft tissue sarcomas demonstrates low mutational burden and recurrent chromosome 1p loss.Human pathology · 2016Article
- Evaluation of ETV4 and WT1 expression in CIC-rearranged sarcomas and histologic mimics.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2016Article
- High-grade undifferentiated small round cell sarcoma with t(4;19)(q35;q13.1) CIC-DUX4 fusion: emerging entities of soft tissue tumors with unique histopathologic features--a case report and literature review.The American journal of case reports · 2015Review
- CIC-DUX sarcomas demonstrate frequent MYC amplification and ETS-family transcription factor expression.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2015Article
- Article
- Chromosome Translocation t(10;19)(q26;q13) in a CIC-sarcoma.In vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study describes a new case of EWSR1-negative undifferentiated sarcoma with CIC/DUX4 gene fusion. This case is similar to tumors described as primitive undifferentiated round cell sarcomas that occur mainly in the trunk and display an aggressive behavior. To our knowledge, this is the first report of such a tumor presenting locoregional lymph node metastasis. In view of previous studies that prove the existence of a particular variant of undifferentiated sarcoma with Ewing-like morphology and CIC/DUX-4 gene fusion, a search for this gene fusion in all undifferentiated round cell sarcomas should be considered if a conclusive diagnosis cannot be reached following other conventional studies. Although additional cases with more extensive follow-up studies are needed, we believe that EWSR1-negative undifferentiated small round cell sarcoma with CIC/DUX4 gene fusion should be added to the list of new sarcoma variants with the possibility of lymph node metastasis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.