ArticleNature nanotechnology2014
Transport and self-organization across different length scales powered by motor proteins and programmed by DNA.
Article in Nature nanotechnology, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 83 citations in OpenAlex.
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- The motive forces in DNA-enabled nanomachinery.iScience · 2024Review
- Structure and dynamics of an archetypal DNA nanoarchitecture revealed via cryo-EM and molecular dynamics simulations.Nature communications · 2023Article
- Actin-microtubule dynamic composite forms responsive active matter with memory.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Nano/Micromotors in Active Matter.Micromachines · 2022Review
- Protein Based Biomaterials for Therapeutic and Diagnostic Applications.Progress in biomedical engineering (Bristol, England) · 2022Article
- Programmed mechano-chemical coupling in reaction-diffusion active matter.Science advances · 2021Article
- Amphiphilic DNA nanostructures for bottom-up synthetic biology.Chemical communications (Cambridge, England) · 2021Review
- A printable active network actuator built from an engineered biomolecular motor.Nature materials · 2021Article
- A Biomimetic DNA-Based Membrane Gate for Protein-Controlled Transport of Cytotoxic Drugs.Angewandte Chemie (Weinheim an der Bergstrasse, Germany) · 2021Article
- A Biomimetic DNA-Based Membrane Gate for Protein-Controlled Transport of Cytotoxic Drugs.Angewandte Chemie (International ed. in English) · 2021Article
- Molecular dynamics simulation of the nanosecond pulsed electric field effect on kinesin nanomotor.Scientific reports · 2019Article
- Binding to nanopatterned antigens is dominated by the spatial tolerance of antibodies.Nature nanotechnology · 2019Article
- Control of swarming of molecular robots.Scientific reports · 2018Article
- Multi-functional DNA nanostructures that puncture and remodel lipid membranes into hybrid materials.Nature communications · 2018Article
- Gold nanocrystal-mediated sliding of doublet DNA origami filaments.Nature communications · 2018Article
- DNA-assisted swarm control in a biomolecular motor system.Nature communications · 2018Article
- Controllable molecular motors engineered from myosin and RNA.Nature nanotechnology · 2018Article
- Non-equilibrium assembly of microtubules: from molecules to autonomous chemical robots.Chemical Society reviews · 2017Review
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5 authors at 1 institution in 1 country.
Funding
Abstract
In eukaryotic cells, cargo is transported on self-organized networks of microtubule trackways by kinesin and dynein motor proteins. Synthetic microtubule networks have previously been assembled in vitro, and microtubules have been used as shuttles to carry cargoes on lithographically defined tracks consisting of surface-bound kinesin motors. Here, we show that molecular signals can be used to program both the architecture and the operation of a self-organized transport system that is based on kinesin and microtubules and spans three orders of magnitude in length scale. A single motor protein, dimeric kinesin-1, is conjugated to various DNA nanostructures to accomplish different tasks. Instructions encoded into the DNA sequences are used to direct the assembly of a polar array of microtubules and can be used to control the loading, active concentration and unloading of cargo on this track network, or to trigger the disassembly of the network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.