ArticleRevista do Instituto de Medicina Tropical de Sao Paulo
Molecular typing of Candida albicans isolates from hospitalized patients.
Article in Revista do Instituto de Medicina Tropical de Sao Paulo. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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10 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic diversity and antifungal resistance in Candida albicans from VVC cases in Indian women.BMC microbiology · 2025Article
- Candidemia: An Update on Epidemiology, Risk Factors, Diagnosis, Susceptibility, and Treatment.Pathogens (Basel, Switzerland) · 2025Review
- Discrimination of Clinical and Food-DerivedPathogens (Basel, Switzerland) · 2025Article
- Advances in Chemical and Biological Methods to Identify Microorganisms-From Past to Present.Microorganisms · 2019Review
- Diagnosis and management of a fatal case of sepsis caused byMedical mycology case reports · 2018Article
- Article
- Virulence factors and genetic variability of vaginal Candida albicans isolates from HIV-infected women in the post-highly active antiretroviral era.Revista do Instituto de Medicina Tropical de Sao Paulo · 2017Article
- Efficient management and maintenance of ultrasonic nebulizers to prevent microbial contamination.World journal of methodology · 2016Article
- Molecular epidemiology of Candida albicans and Candida glabrata strains isolated from intensive care unit patients in Poland.Memorias do Instituto Oswaldo Cruz · 2014Article
- COMPARISON BETWEEN FOUR USUAL METHODS OF IDENTIFICATION OF Candida SPECIES.Revista do Instituto de Medicina Tropical de Sao PauloArticle
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Authors and funding
6 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionThe majority of nosocomial fungal infections are caused by Candida spp. where C. albicans is the species most commonly identified. Molecular methods are important tools for assessing the origin of the yeasts isolated in hospitals.
methodsThis is a study on the genetic profiles of 39 nosocomial clinical isolates of C. albicans using two typing methods: random amplified polymorphic DNA (RAPD) and microsatellite, two different primers for each technique were used.
resultsRAPD provided 10 and 11 different profiles with values for S(AB) of 0.84 ± 0.126 and 0.88 ± 0.08 for primers M2 and P4, respectively. Microsatellite using two markers, CDC3 and HIS3, allowed the observation of six and seven different alleles, respectively, with combined discriminatory power of 0.91.
conclusionsAlthough genetic variability is clear, it was possible to identify high similarity, suggesting a common origin for at least a part of isolates. It is important to emphasize that common origin was proven from yeasts isolated from colonization (urine, catheter or endotracheal secretions) and blood culture from the same patient, indicating that the candidemia must have started from a site of colonization. The combination of RAPD and microsatellite provides a quick and efficient analysis for investigation of similarity among nosocomial isolates of C. albicans.
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