ArticleCancers2011
Inhibitory Effect of a γ-Tocopherol-Rich Mixture of Tocopherols on the Formation and Growth of LNCaP Prostate Tumors in Immunodeficient Mice.
Article in Cancers, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- DNA methylome, transcriptome, and prostate cancer prevention by phenethyl isothiocyanate in TRAMP mice.Molecular carcinogenesis · 2021Article
- Role of opiorphin genes in prostate cancer growth and progression.Future oncology (London, England) · 2021Article
- δ-Tocopherol inhibits the development of prostate adenocarcinoma in prostate specific Pten-/- mice.Carcinogenesis · 2018Article
- Taxifolin Activates the Nrf2 Anti-Oxidative Stress Pathway in Mouse Skin Epidermal JB6 P+ Cells through Epigenetic Modifications.International journal of molecular sciences · 2017Article
- Inhibitory Effects of γ- and δ-Tocopherols on Estrogen-Stimulated Breast CancerCancer prevention research (Philadelphia, Pa.) · 2017Article
- δ- and γ-tocopherols inhibit phIP/DSS-induced colon carcinogenesis by protection against early cellular and DNA damages.Molecular carcinogenesis · 2017Article
- What Are the Links of Prostate Cancer with Physical Activity and Nutrition? : A Systematic Review Article.Iranian journal of public health · 2016Review
- Tocopherols in cancer: An update.Molecular nutrition & food research · 2016Review
- Dietary tocopherols inhibit PhIP-induced prostate carcinogenesis in CYP1A-humanized mice.Cancer letters · 2016Article
- A Perspective on Prostate Carcinogenesis and Chemoprevention.Current pharmacology reports · 2015Article
- α-Tomatine inhibits growth and induces apoptosis in HL-60 human myeloid leukemia cells.Molecular medicine reports · 2015Article
- Potent inhibitory effect of δ-tocopherol on prostate cancer cells cultured in vitro and grown as xenograft tumors in vivo.Journal of agricultural and food chemistry · 2014Article
- Blocking of JB6 cell transformation by tanshinone IIA: epigenetic reactivation of Nrf2 antioxidative stress pathway.The AAPS journal · 2014Article
- Cancer prevention by tocopherols and tea polyphenols.Cancer letters · 2013Review
- A γ-tocopherol-rich mixture of tocopherols maintains Nrf2 expression in prostate tumors of TRAMP mice via epigenetic inhibition of CpG methylation.The Journal of nutrition · 2012Article
- Does vitamin E prevent or promote cancer?Cancer prevention research (Philadelphia, Pa.) · 2012Review
- δ- and γ-tocopherols, but not α-tocopherol, inhibit colon carcinogenesis in azoxymethane-treated F344 rats.Cancer prevention research (Philadelphia, Pa.) · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 1 country.
Funding
Abstract
In the present study, we determined the effects of a γ-tocopherol-rich mixture of tocopherols (γ-TmT) on the growth and apoptosis of cultured human prostate cancer LNCaP cells. We also determined the effects of dietary γ-TmT on the formation and growth of LNCaP tumors in immunodeficient mice. In the in vitro study, we found that the activity of γ-TmT was stronger than α-tocopherol for inhibiting the growth and stimulating apoptosis in LNCaP cells. In the animal study, treatment of severe combined immunodeficient (SCID) mice with dietary γ-TmT inhibited the formation and growth of LNCaP xenograft tumors in a dose-dependent manner. Mechanistic studies showed that g-TmT administration inhibited proliferation as reflected by decreased mitosis and stimulated apoptosis as reflected by increased caspase-3 (active form) expression in LNCaP tumors. In addition, dietary administration of g-TmT increased the levels of a-, γ- and δ- tocopherol in plasma, and increased levels of γ- and δ- tocopherol were also observed in the prostate and in tumors. The present study demonstrated that g-TmT had strong anticancer activity both in vitro and in vivo. Additional studies are needed to determine the potential preventive effect of g-TmT for prostate cancer in humans.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.