Trial reportRevista Brasileira de terapia intensiva
The implementation of an analgesia-based sedation protocol reduced deep sedation and proved to be safe and feasible in patients on mechanical ventilation.
Trial report in Revista Brasileira de terapia intensiva. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 4 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- 2021 KSCCM clinical practice guidelines for pain, agitation, delirium, immobility, and sleep disturbance in the intensive care unit.Acute and critical care · 2022Guideline
- Prevalence of post-traumatic stress disorder symptoms in adult critical care survivors: a systematic review and meta-analysis.Critical care (London, England) · 2019Pooled it
- Protocol-directed sedation versus non-protocol-directed sedation in mechanically ventilated intensive care adults and children.The Cochrane database of systematic reviews · 2018Pooled it
- Sedation protocols versus daily sedation interruption: a systematic review and meta-analysis.Revista Brasileira de terapia intensivaPooled it
- Comparison between Dexmedetomidine and Midazolam for Sedation in Patients with Intubation after Oral and Maxillofacial Surgery.BioMed research international · 2020Trial
- [Efficacy of analgesic and sedative treatments in children with mechanical ventilation in the pediatric intensive care unit].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Trial
- Saudi Guideline for Mechanical Ventilation in Adults.Saudi journal of medicine & medical sciences · 2026Article
- Observational
- Factors associated with long-term mechanical ventilation in patients undergoing cardiovascular surgery.BMC cardiovascular disorders · 2023Article
- The Profile of Early Sedation Depth and Clinical Outcomes of Mechanically Ventilated Patients in Korea.Journal of Korean medical science · 2023Article
- Prevalence and Influencing Factors of Physical Restraints in Intensive Care Units: A Retrospective Cohort Study.Risk management and healthcare policy · 2023Article
- The ABCDEF Bundle for the Respiratory Therapist.Respiratory care · 2019Review
- Sedation and neuromuscular blocking agents in acute respiratory distress syndrome.Annals of translational medicine · 2017Review
- Review
- Comparison of propofol-hydromorphone and propofol-dexmedetomidine in patients with intubation after maxillofacial plastic surgery.Therapeutics and clinical risk management · 2016Article
- Evaluation of a minimal sedation protocol using ICU sedative consumption as a monitoring tool: a quality improvement multicenter project.Critical care (London, England) · 2014Article
- Implementing sedation protocols: closing the evidence-practice gap.Revista Brasileira de terapia intensivaArticle
- Sedation for adult ICU patients: A narrative review including a retrospective study of our own data.Saudi journal of anaesthesiaReview
Corrections and comments
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Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionDeep sedation in critically ill patients is associated with a longer duration of mechanical ventilation and a prolonged length of stay in the intensive care unit. Several protocols have been used to improve these outcomes. We implement and evaluate an analgesia-based, goal-directed, nurse-driven sedation protocol used to treat critically ill patients who receive mechanical ventilation.
methodsWe performed a prospective, two-phase (before-after), non-randomized multicenter study that involved 13 intensive care units in Chile. After an observational phase (observational group, n=155), we designed, implemented and evaluated an analgesia-based, goal-directed, nurse-driven sedation protocol (intervention group, n=132) to treat patients who required mechanical ventilation for more than 48 hours. The primary outcome was to achieve ventilator-free days by day 28.
resultsThe proportion of patients in deep sedation or in a coma decreased from 55.2% to 44.0% in the interventional group. Agitation did not change between the periods and remained approximately 7%. Ventilator-free days to day 28, length of stay in the intensive care unit and mortality were similar in both groups. At one year, post-traumatic stress disorder symptoms in survivors were similar in both groups.
conclusionsWe designed and implemented an analgesia-based, goal-directed, nurse-driven sedation protocol in Chile. Although there was no improvement in major outcomes, we observed that the present protocol was safe and feasible and that it resulted in decreased periods of deep sedation without increasing agitation.
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