ArticleAge and ageing2014
Parental longevity is associated with cognition and brain ageing in middle-aged offspring.
Article in Age and ageing, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 2 of them syntheses that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- The Well-Being of the Elderly: Memory and Aging.Frontiers in psychology · 2020Pooled it
- Characterization of White Matter Hyperintensities in Large-Scale MRI-Studies.Frontiers in neurology · 2019Pooled it
- Article
- Pathway analysis of cognitive resilience factors and cognitive function in the Long Life Family Study (LLFS).Neuropsychology · 2026Observational
- Gray Matter Covariance Networks Associated With Parental Longevity-Results From the LonGenity Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- The Association of Circulating Immune Cells With Cognitive Function, Brain Imaging, and Incident All-cause and Alzheimer's Dementia: The Framingham Offspring Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025Article
- Inflammatory protein associations with brain MRI measures: Framingham Offspring Cohort.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Cognitive reserve proxies are associated with age-related cognitive decline - Not age-related gait speed decline.Neurobiology of aging · 2024Article
- The Biomarkers in Extreme Longevity: Insights Gained from Metabolomics and Proteomics.International journal of medical sciences · 2024Review
- Genome-wide association of polygenic risk extremes for Alzheimer's disease in the UK Biobank.Scientific reports · 2022Article
- Article
- Article
- Cross-Sectional Association Between Blood Cell Phenotypes, Cognitive Function, and Brain Imaging Measures in the Community-Based Framingham Heart Study.Journal of Alzheimer's disease : JAD · 2022Article
- The relationship of parental longevity with the aging brain-results from UK Biobank.GeroScience · 2020Article
- Reduced Prevalence and Incidence of Cognitive Impairment Among Centenarian Offspring.The journals of gerontology. Series A, Biological sciences and medical sciences · 2019Article
- Genome-wide Association Study of Parental Life Span.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Improved lipids, diastolic pressure and kidney function are potential contributors to familial longevity: a study on 60 Chinese centenarian families.Scientific reports · 2016Article
- Genome maintenance and human longevity.Current opinion in genetics & development · 2014Review
- Normative data for 8 neuropsychological tests in older blacks and whites from the atherosclerosis risk in communities (ARIC) study.Alzheimer disease and associated disordersArticle
- Establishing cognitive baseline in three generations: Framingham Heart Study.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundoffspring of long-lived individuals have lower risk for dementia. We examined the relation between parental longevity and cognition and subclinical markers of brain ageing in community-dwelling adult offspring.
methodsoffspring participants with both parents in the Framingham Heart Study, aged ≥55 years and dementia-free underwent baseline and repeat neuropsychological (NP) testing and brain magnetic resonance imaging (MRI). Parental longevity was defined as having at least one parent survive to age ≥85 years. To test the association between parental longevity and measures of cognition and brain volumes, we used multivariable linear and logistic regression adjusting for age, sex, education and time to NP testing or brain MRI.
resultsof 728 offspring (mean age 66 years, 54% women), 407 (56%) had ≥1 parent achieve longevity. In cross-sectional analysis, parental longevity was associated with better scores on attention (beta 0.21 ± 0.08, P = 0.006) and a lower odds of extensive white matter hyperintensity on brain MRI (odds ratio 0.59, 95% CI: 0.38, 0.92, P = 0.019). The association with white matter hyperintensity was no longer significant in models adjusted for cardiovascular risk factors and disease. In longitudinal analysis (6.7 ± 1.7 years later), offspring with parental longevity had slower decline in attention (0.18 ± 0.08, P = 0.038), executive function (beta 0.19 ± 0.09, P = 0.031) and visual memory (beta -0.18 ± 0.08, P = 0.023), and less increase in temporal horn volume (beta -0.25 ± 0.09, P = 0.005). The associations persisted in fully adjusted models.
conclusionparental longevity is associated with better brain ageing in middle-aged offspring.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.