ArticleNature genetics2014
Genome-wide association study using cellular traits identifies a new regulator of root development in Arabidopsis.
Article in Nature genetics, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 78 papers.
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Who cites it
78 citing papers in PubMed.
- GWAS reveal SUBER GENE1-mediated suberization via type one phosphatases.Nature plants · 2026Article
- Host genome and bacterial taxa shape the Arabidopsis seed microbiome.EMBO reports · 2026Article
- Genetic analysis of common bean (Phaseolus vulgaris L.) genotypes for root traits, yield components and seed yield.Journal of applied genetics · 2025Article
- Natural variation of TBR confers plant zinc toxicity tolerance through root cell wall pectin methylesterification.Nature communications · 2024Article
- Identification of Quantitative Trait Loci Controlling Root Morphological Traits in an Interspecific Soybean Population Using 2D Imagery Data.International journal of molecular sciences · 2024Article
- Tapping into the plasticity of plant architecture for increased stress resilience.F1000Research · 2023Review
- Combined Approach of GWAS and Phylogenetic Analyses to Identify New Candidate Genes That Participate inPlants (Basel, Switzerland) · 2022Article
- The receptor kinase SRF3 coordinates iron-level and flagellin dependent defense and growth responses in plants.Nature communications · 2022Article
- Genome-Wide Association Studies Reveal Novel Loci for Herbivore Resistance in Wild Soybean (International journal of molecular sciences · 2022Article
- Recent Advances in Agronomic and Physio-Molecular Approaches for Improving Nitrogen Use Efficiency in Crop Plants.Frontiers in plant science · 2022Review
- Genome-Wide Association Study Reveals the Genetic Basis of Five Quality Traits in Chinese Wheat.Frontiers in plant science · 2022Article
- Review
- Association mapping of drought tolerance and agronomic traits in rice (Oryza sativa L.) landraces.BMC plant biology · 2021Article
- Meta-QTLs, ortho-MQTLs and candidate genes for nitrogen use efficiency and root system architecture in bread wheat (Physiology and molecular biology of plants : an international journal of functional plant biology · 2021Article
- A novel motif in the 5'-UTR of an orphan gene 'Big Root Biomass' modulates root biomass in sesame.Plant biotechnology journal · 2021Article
- A genome-wide association study reveals cytokinin as a major component in the root defense responses against Ralstonia solanacearum.Journal of experimental botany · 2021Article
- GWAS Mediated Elucidation of Heterosis for Metric Traits in Cotton (Frontiers in plant science · 2021Article
- Genome-wide dissection of hybridization for fiber quality- and yield-related traits in upland cotton.The Plant journal : for cell and molecular biology · 2020Article
- Genotype networks of 80 quantitative Arabidopsis thaliana phenotypes reveal phenotypic evolvability despite pervasive epistasis.PLoS computational biology · 2020Article
- AraPheno and the AraGWAS Catalog 2020: a major database update including RNA-Seq and knockout mutation data for Arabidopsis thaliana.Nucleic acids research · 2020Article
18 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
With the increased availability of high-resolution sequence information, genome-wide association (GWA) studies have become feasible in a number of species. The vast majority of these studies are conducted in human populations, where it is difficult to provide strong evidence for the functional involvement of unknown genes that are identified using GWA. Here we used the model organism Arabidopsis thaliana to combine high-throughput confocal microscopy imaging of traits at the cellular level, GWA and expression analyses to identify genomic regions that are associated with developmental cell-type traits. We identify and characterize a new F-box gene, KUK, that regulates meristem and cell length. We further show that polymorphisms in the coding sequence are the major causes of KUK allele-dependent natural variation in root development. This work demonstrates the feasibility of GWA using cellular traits to identify causal genes for basic biological processes such as development.
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